Psoriasis is linked to systemic inflammation and cardiovascular comorbidities, but studies of the underlying cellular mechanisms are lacking. The NLRP3 inflammasome genetically associated with psoriasis, its activation increasingly disease. In this study, we show that patients psoriasis exhibited higher plasma levels inflammasome-generated IL-1? IL-18, without any correlation skin lesion severi...

background inflammatory bowel disease (ibd) is a chronic, relapsing, inflammatory disorder of the gastrointestinal tract that includes two entities, crohn`s disease (cd) and ulcerative colitis (uc). as with other complex diseases, both genetic susceptibility and environmental factors play role in the pathogenesis of these diseases. the tumor necrosis factor α (tnf-α) gene is located in the ibd3...