Reverse and forward mutation, induced by photoaddition of 8-methoxypsoralen (8-MOP) and 3-carbethoxypsoralen (3-CPs) or ultraviolet light (UV), are reduced in three pso mutants of Saccharomyces cerevisiae. The pso1-1 strain exhibits a lower frequency of spontaneous reversion (anti-mutator) and is almost entirely unaffected by the three agents in both the haploid and diploid states. The pso2-1 s...

Myeloperoxidase (MOP) is present in monocyte and neutrophil lysosomes, catalyzing hydrogen peroxide and chloride ion conversion to hypochlorous acid. MOP seems to destroy pathogens during phagocytosis by neutrophils and is considered an important defense against innumerous bacteria. We present a patient who had MOP deficiency, who presented with a subacute form of paracoccidioidomycosis and lat...

Endosomal trafficking of signaling proteins plays an essential role in cellular homeostasis. The seven-pass transmembrane protein Frizzled (Fz) is a critical component of Wnt signaling. Although Wnt signaling is proposed to be regulated by endosomal trafficking of Fz, the molecular events that enable this regulation are not completely understood. Here we show that the endosomal protein Myopic (...

multiple objective programming (mop) problems have become famous among many researchers due to more practical and realistic implementations. there have been a lot of methods proposed especially during the past four decades. in this paper, we develop a new algorithm based on a new approach to solve mop problems by starting from a utopian point (which is usually infeasible) and moving towards the...

OBJECTIVES Hips with metal-on-metal total hip arthroplasty (MoM THA) have a high rate of adverse local tissue reactions (ALTR), often associated with hypersensitivity reactions. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) measures tissue perfusion with the parameter Ktrans (volume transfer constant of contrast agent). Our purpose was 1) to evaluate the feasibility of DCE-MRI ...

We describe a runtime verification approach to increase the safety of IVHM systems by an integration of TEAMS models and MOP (Monitor-Oriented Programming). The TEAMS model is used to automatically extract relevant runtime information from the controlled system by means of events. This information is passed on-line to the MOP engine, allowing to verify complex temporal properties and to discove...

Induction of unscheduled DNA synthesis (UDS) by 8-methoxypsoralen (8-MOP) plus ultraviolet A (UV-A) (PUVA) was investigated in the epidermis of female hairless mice by means of an in vivo--in vitro assay using a liquid scintillation counting method. Groups of three to five 8-week-old female hairless mice had 8-MOP applied once onto two areas of the back after stripping of the stratum corneum wi...

We study a recent programming paradigm known as Adaptive Programming (AP) as an ideal candidate for a metaobject protocol (MOP) for object-oriented programming languages; we call it the AP MOP. The major beneet of the AP MOP is to provide a mechanism for writing base-level programs in a structure-shy manner. Doing so, the programs are more robust to changes in the structural aspects of the appl...