A simple and efficient copper-catalyzed method for synthesis of naphthols containing multifunctional groups has been developed under mild conditions (room temperature to 60 °C), and it can tolerate various functional groups.

Herein, a direct C8-oxygenation of naphthalene derivatives is described. Different carbonyl groups were used as directing group to deliver corresponding naphthols via palladium-catalyzed oxidation reaction using PhI(OAc)2 in TFA/TFAA mixture. Interestingly, when Weinreb amide was employed the group, naphtholactone skeleton directly obtained. This methodology applied synthesis variously substitu...

An organocatalytic asymmetric chlorinative dearomatization of naphthols was realized for the first time, providing chiral naphthalenones with a Cl-containing all-substituted stereocenter in excellent yields and enantioselectivity (up to 97% yield and 96% ee). The reaction features mild reaction conditions, good tolerance of diverse functional groups and simple reaction operation.

An efficient and environmentally benign one-pot condensation of cyclic diketones, aldehydes naphthols was achieved with 1,4-diazabicyclo[2-2-2]octane supported on Amberlyst-15 as a novel catalyst, producing variety benzoxanthenones in good to excellent yields. The advantages this multicomponent reaction include the use heterogeneous solventless conditions simple methodology that is atom-economi...

The different reactivity of two kinds of carbonyl groups in keto aldehyde substrates has been exploited for the synthesis of phenanthrols, naphthols, and their heteroatom-containing analogues. Key to this highly efficient and robust methodology is the catalyst-free intramolecular formal diazo carbon insertion of N-tosylhydrazones into keto C-C bonds.

A series of photochromic 2,2,4,6-tetraaryl-2 H -benzo[ h ]chromenes have been efficiently synthesised by two complementary strategies employing the condensation 1,1,3-triarylprop-2-yn-1-ols with 4-substituted 1-naphthols and Suzuki cross-coupling chemistry. The novel 1,1,3-triarylpropynols were readily obtained either addition an arylacetylide to requisite benzophenones or a Sonogashira couplin...