Abstract An efficient and straightforward approach has been established for the preparation of a new class depsipeptide structures via isocyanide-based consecutive Bargellini–Passerini multicomponent reactions. 3-Carboxamido-isobutyric acids bearing an amide bond were obtained Bargellini reaction from isocyanides, acetone, chloroform in presence sodium hydroxide. Next, Passerini multicomponent-...

Increasing the diversity of peptide cyclization methods is an effective way of accessing new types of macrocyclic chemotypes featuring a wide variety of ring sizes and topologies. Multicomponent reactions (MCRs) are processes capable of generating great levels of molecular diversity and complexity at low synthetic cost. In an attempt to further exploit MCRs in the field of cyclopeptides, we des...

New multicomponent domino reactions of arylglyoxals with pyrazol-5-amines have been established, providing selective access to unprecedented pyrazolo-fused 1,7-naphthyridines, 1,3-diazocanes, and pyrroles (up to 52 examples). The unreported dipyrazolo-fused 1,7-naphthyridines were regioselectively synthesized through a special double [3 + 2 + 1] heteroannulation accompanied by direct C-C format...

The Front Cover illustrates how multicomponent reactions offer dreamlike opportunities for the conversion of biobased scaffold 5-Hydroxymethylfurfural (HMF) towards complex structures, and ammonium acetate acts as a mild catalyst such [4+2+1] cycloadditions acid-sensitive substrates. This “enchanted” cover, sponsored by INSA Lyon, was designed Lyon artist Adrien Demingeon (https://www.instagram...

An efficient and one-pot procedure for the synthesis of arylated and stereodefined allylic alcohols has been achieved through zirconium-mediated multicomponent coupling reactions of alkynes, aldehydes (or ketones), and aryl iodides. The subsequent intramolecular Friedel-Crafts reactions of these allylic alcohols catalyzed by Brønsted or Lewis acids afford highly substituted indenes and spiroind...

Abstract C 18 H 12 O, triclinic, P 1 ‾ $P‾{1}$ (no. 2), a = 10.132(2) Å, b 10.654(2) c 11.730(2) α 90.31(3)°, β 102.38(3)°, γ 104.81(3)°, V 1193.2(4) Å 3 , Z 4, R gt ( F ) 0.0403, wR ref 2 0.1037, T 293(2) K.