Systemic lupus erythmatosus is a chronic autoimmune disease characterized by abnormal immune response with overproduction of auto-antibodies, self-destructive complexes and hyperactivity of both T and B lymphocytes. Although the exact pathogenesis of SLE remains unclear, it has been found that the imbalance of Th1/Th2, subsequent cytokines and antior pro-inflammatory mediators could reflect the...

A High-Speed Low-Noise CIS with 12b 2-stage Pipelined Cyclic ADCs JongHo Park*, Satoshi Aoyama*, Takashi Watanabe*, Tomohiko Kosugi*, Zheng Liu*, Tomoyuki Akahori*, Masaaki Sasaki*, Keigo Isobe*, Yuichi Kaneko*, Kazuki Muramatsu*, Tetsuya Iida*, and Shoji Kawahito* *Brookman Technology, Inc., 3-1-7 Wajiyama, Nakaku, Hamamatsu 432-8003, Japan Phone/Fax: +81-53-474-4540, E-mail:parkjh@brookmantec...

Starting from enantiomeric pure 1-[(3S,5R)- and 1-[(3R,5S)-3-(hydroxymethyl)-2-methylisoxazolidin-5-yl]-5-methylpyrimidine-2,4(1H,3H)-diones (-)7a and (+)7b, obtained by lipase-catalyzed resolution, pure diethyl{[(3S,5R)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)isoxazolidin-3-yl]methyl}phosphonate (-)12a and diethyl{[(3R,5S)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidi...

The aim of our study was to investigate the association between common polymorphisms in interleukin-12 (IL-12) and rheumatoid arthritis (RA) risk using meta-analysis. A search was conducted in the PubMed database, covering all papers published by October 14, 2015. Odds ratios (OR) and 95% confidence intervals (CI) were used to evaluate the strength of this association. Publication bias was asse...

In the present study, we investigate and compare the efficacy of bone marrow- and adipose tissue-derived mesenchymal stem cell (MSCs) in corneal wound healing. A penetrating injury was created in the right corneas of Wistar rats (n = 40). Ten microliters of phosphate-buffered solution (PBS) containing 2 × 10(5) green fluorescent protein (GFP) labeled bone-marrow-derived MSCs to group 1 (n = 15)...

INTRODUCTION ES-62, a phosphorylcholine (PC)-containing immunomodulator secreted by the parasitic worm Acanthocheilonema viteae, protects against nephritis in the MRL/Lpr mouse model of systemic lupus erythematosus (SLE). However, ES-62 is not suitable for development as a therapy and thus we have designed drug-like small molecule analogues (SMAs) based around its active PC-moiety. To provide p...

Ethyl-2-amino-4,5,6,7-tetrahydro-1-benzoselenophene-3-carboxylate (4), has been prepared as a potential dual-acting selenium-containing allosteric enhancer of adenosine A(1)A receptor binding utilising a modified Gewald reaction. While preliminary testing indicated that 4 is a superior enhancer of A(1)AR binding than its thiophene counterpart, its instability under mildly acidic conditions is c...

background : cytokines produced by different subsets of t cells are the key mediators to adjust the quality of immune responses. despite evidence of induction of an immune reaction against tumors such as breast cancer, not all responses are protective. in this study we attempt to evaluate the expression profile of several cytokines from the t helper 1 and 2 subsets in blood cells from patients ...

67 www.ijntr.org Abstract—Genome-wide association studies of psoriasis identified interleukin (IL)-12B and IL-23R as significantly associated loci with psoriasis, thus emphasizing to the important role of these genes in the pathogenesis of this disease and have influenced the development of medications that specifically target these key immunological players. Here we report an association study...