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HIV type-1 (HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTIs) are key drugs of highly active antiretroviral therapy (HAART) in the clinical management of AIDS/HIV infection. NNRTI-based HAART regimes effectively suppress viral reproduction, are not cytotoxic and show favourable pharmacokinetic properties. First-generation NNRTIs suffer the rapid selection of viral variants, hamper...

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When the electron density is a linear function of distance, it is known that the MSW equations for two neutrino species can be solved in terms of known functions. It is shown here that more generally, for any number of neutrino species, these MSW equations can be solved exactly in terms of single integrals. While these integrals cannot be expressed in terms of known functions, some of their sim...

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To investigate a potential causal role of natural variation in endogenous testosterone levels the development acne, we performed two-sample sex-stratified Mendelian randomisation (MR) study. Instrumental variables comprised genetic variants with genome-wide significant effects on total (TT), free (FT) and steroid hormone binding globulin (SHBG) male female participants UK Biobank. The these ins...