BACKGROUND Tenofovir (TFV) causes kidney tubular dysfunction (KTD) in some patients, but the mechanism is poorly understood. Genetic variants in TFV transporters are implicated; we explored whether ABCC10 transports TFV and whether ABCC10 single-nucleotide polymorphisms (SNPs) are associated with KTD. METHODS TFV accumulation was assessed in parental and ABCC10-transfected HEK293 cells (HEK29...

Methods of analogous reasoning and case-based reasoning for intelligent decision support systems are considered. Special attention is drawn to methods based on a structural analogy that take the context into account. This work was supported by RFBR (projects 02-07-90042, 05-07-90232). ACM Classification

Modern Concepts & Developments in Agronomy Computational Tools and Phytopathogenic Fungi Secretome: Unraveling the Protein Arsenal Mariana Regina Almas do Carmo1, Tulio Morgan1, Rafael Ferreira Alfenas2 Gabriela Piccolo Maitan-Alfenas1* 1Department of Biochemistry Molecular Biology, Brazil 2Department Phytopathology, *Corresponding author: Maitan-Alfenas, Department Federal University Viçosa, S...

BACKGROUND The objective of this work was to evaluate the time course of clinical and health-related quality of life outcomes of long-stay ICU survivors' and caregivers' burden. METHODS The study included 23 subjects of mixed diagnosis (66 ± 11 y, body mass index 26.5 ± 5.6 kg/m(2)) with a recent episode of acute respiratory failure needing in-hospital rehabilitation. Subjects and caregivers ...

OBJECTIVE To investigate the association of HLA class II alleles with the susceptibility to sudden sensorineural hearing loss and with the results of corticosteroid treatment in the Korean population. DESIGN HLA-DRB1, -DQA1, -DQB1, and -DPB1 genotyping by the sequence-specific oligonucleotide probes method in 41 patients with sudden sensorineural hearing loss and in 206 healthy control subjec...

Potentiometric and spectrophotometric pH-titration of the multiprotic cytostatics bosutinib for dissociation constants determination were compared. Bosutinib treats patients with positive chronic myeloid leukemia. Bosutinib exhibits four protonatable sites in a pH range from 2 to 11, where two pK are well separated (ΔpK>3), while the other two are near dissociation constants. In the neutral med...

The aim of this study was to assess the appearance of cardiac troponins (cTnI and/or cTnT) after a short bout (30 s) of 'all-out' intense exercise and to determine the stability of any exercise-related cTnI release in response to repeated bouts of high intensity exercise separated by 7 days recovery. Eighteen apparently healthy, physically active, male university students completed two all-out ...

Review of International Studies / Volume 38 / Issue 05 / December 2012, pp 931 942 DOI: 10.1017/S026021051200040X, Published online: 02 January 2013 Link to this article: http://journals.cambridge.org/abstract_S026021051200040X How to cite this article: LUCA MAVELLI and FABIO PETITO (2012). The postsecular in International Relations: an overview. Review of International Studies, 38, pp 931-942 ...

May 11, 2010 Title Latent Variable Analysis Version 0.3-1 Author Yves Rosseel Maintainer Yves Rosseel Description Fit a variety of latent variable models, including confirmatory factor analysis, structural equation modeling and latent growth curve models. Depends R (>= 2.10.1), methods License GPL-2 LazyLoad yes LazyData yes URL http://lavaan.org ...