MicroRNAs (miRNAs) are a group of small non‑coding RNA molecules, which serve an important function in the development of multidrug resistance in cancer through the post‑transcriptional regulation of gene expression and RNA silencing. In the present study, the functional effects of miR‑197 were analyzed in chemo‑resistant gastric cancer cells. Low expression levels of miR‑197 were observed in t...

Directed and elliptic flow for the Au + Au system at incident energies between 40 and 150 MeV per nucleon has been measured using the INDRA 4π multiPreprint submitted to Elsevier Science 21 October 2004 detector. For semi-central collisions, the elliptic flow of Z ≤ 2 particles switches from in-plane to out-of-plane enhancement at around 100 MeV per nucleon, in good agreement with the result re...

PURPOSE The presence of TNF-α in approximately 50% of surgically resected tumors suggests that the canonical NF-κB and the mTOR pathways are activated. Inhibitor of IκB kinase β (IKKβ) acts as the signaling node that regulates transcription via the p-IκBα/NF-κB axis and regulates translation via the mTOR/p-S6K/p-eIF4EBP axis. A kinome screen identified a quinoxaline urea analog 13-197 as an IKK...

We study particle production of coherently oscillating inflaton in the semiclassical theory of gravity by representing inflaton in coherent and squeezed state formalisms. A comparative study of the inflaton in classical gravity with coherent state inflaton in semiclassical gravity is also presented. email: [email protected] ∗Corresponding address : P.K.Suresh, School of Physics,University of...

OKY 046, a specific thromboxane synthase inhibitor, was used to investigate whether large pulmonary emboli, like microemboli, cause an increase in thromboxane A2 and an associated increase in vascular permeability in sheep. Nineteen sheep were anaesthetised and had cannulas inserted into the afferent lymphatic of the caudal mediastinal lymph node and pulmonary and carotid arteries. Several days...

Malignant pleural mesothelioma (MPM) is an aggressive disease with a poor prognosis. Studies have shown that both MET and its key downstream intracellular signaling partners, PI3K and mTOR, are overexpressed in MPM. Here we determined the combinatorial therapeutic efficacy of a new generation small molecule inhibitor of MET, ARQ 197, and dual PI3K/mTOR inhibitors NVP-BEZ235 and GDC-0980 in meso...