Phytocannabinoids that do not produce psychotropic effects are considered of special interest as novel therapeutic agents in CNS diseases. A cannabigerol quinone, the compound VCE-003, has been shown to alleviate symptoms in a viral model of multiple sclerosis (MS). Hence, we studied T cells and macrophages as targets for VCE-003 and its efficacy in an autoimmune model of MS. Proliferation, cel...

NB-003 and NB-003 gel formulations are oil-in-water nanoemulsions designed for use in bacterial infections. In vitro susceptibility of Propionibacterium acnes to NB-003 formulations and comparator drugs was evaluated. Both NB-003 formulations were bactericidal against all P. acnes isolates, including those that were erythromycin, clindamycin, and/or tetracycline resistant. In the absence of seb...

Both policosanol and D-003 are mixtures of higher aliphatic alcohols and acids, respectively, purified from sugarcane wax, whose main components are octacosanol and octacosanoic acid (an active metabolite of octacosanol), respectively. Both substances share some, not all, pharmacological effects, like cholesterol-lowering, antiplatelet and antioxidant effects. The mechanisms whereby they exhibi...

PURPOSE Cancer cells are highly dependent on folate metabolism, making them susceptible to drugs that inhibit folate receptor activities. Targeting overexpressed folate receptor alpha (FRα) in cancer cells offers a therapeutic opportunity. We investigated the functional mechanisms of MORAB-003 (farletuzumab), a humanized mAb against FRα, in ovarian cancer models. EXPERIMENTAL DESIGN We first ...

Towards the end of the BeppoSAX mission, the only operated Narrow Field Instrument was the PDS, which covers the energy range 13-300 keV. Two blazars, 1ES 0507-040 (z = 0.304) and PKS 1229-021 (z = 1.045), suitably located in the sky for BeppoSAX pointing, were observed for about 2 days each in Spring 2002 with the PDS and detected up to 50 keV. 1ES0507-040 had been already observed by the Bepp...

We report the spectroscopic changes of tetraphenylporphyrin carbon nanotube composites in a variety of chlorinated solvents such as chloroform, dichloroethane and dichlorobenzene as a result of sonication. Detailed data analysis suggests that protonation of the porphyrin core nitrogen atoms occurs as a result of sonodegradation of the solvent molecules. Extreme care must be taken when working w...

OBJECTIVE To collect information about the types, frequency, importance, and quality of mentorship received among academic family medicine faculty, and to identify variables associated with receiving high-quality mentorship. DESIGN Web-based survey of all faculty members of an academic department of family medicine. SETTING The Department of Family and Community Medicine of the University o...

OBJECTIVE Posttraumatic stress disorder (PTSD) is an independent risk factor for cardiovascular diseases. This study investigated the molecular mechanisms underlying myocardial injury induced by simulated PTSD. METHODS Sprague-Dawley rats were randomly divided into two groups: control group (n = 18) and PTSD group (n = 30). The PTSD model was replicated using the single prolonged stress (SPS)...