Profilin-1 (PFN-1) is an actin-binding protein that regulates actin polymerization, cell proliferation, apoptosis, angiogenesis, and carcinogenesis. Its dysregulation has been reported in diverse pathologic diseases; however, the role of PFN-1 psoriasis not yet elucidated. In this study, we demonstrate expression increased both skin serum patients with psoriasis. was markedly expressed epidermi...

Flexible perovskite solar cells (f-PSCs) are light-weight, conformal and thus ideal for seamless integration of photovoltaics onto wearable portable electronics. Nevertheless, the spread f-PSCs is limited by both lower efficiency compared to rigid counterparts employment costly materials. Among them, hole-transporting materials (HTM) represent most expensive component also a weak spot long-term...

Outbreaks due to Clostridium difficile polymerase chain reaction (PCR) ribotype 027, toxinotype III, were detected in 7 hospitals in the Netherlands from April 2005 to February 2006. One hospital experienced at the same time a second outbreak due to a toxin A-negative C. difficile PCR ribotype 017 toxinotype VIII strain. The outbreaks are difficult to control.

The mammalian target of rapamycin (mTOR) and phosphoinositide-3-kinase (PI3K) pathways are often aberrantly activated in acute myeloid leukemia (AML) and play critical roles in proliferation and survival of leukemia cells. We provide evidence that simultaneous targeting of mTOR complexes with the catalytic mTOR inhibitor OSI-027 and of the p110α subunit of PI3K with the specific inhibitor BYL-7...

Five age groups (CA 7-9, 10-12, 13-16,120-21,^027) of Ss were selected from two contrasting populations in Urban and Rural Yucatan, Mexico. All Urban Ss were in school, while only the two younger Rural age groups were in school--older Rural Ss had little or no schooling. The Ss were tested on a short-term and inciden-

Cui Tang 1,2,* ID , Xianggen Yin 1,2 and Zhe Zhang 1,2 1 State Key Laboratory of Advanced Electromagnetic Engineering and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; [email protected] (X.Y.); [email protected] (Z.Z.) 2 Electric Power Security and High Efficiency Laboratory, Huazhong University of Science and Technology, Wuhan 430074, China * Correspondence:...

Elimination of Clostridium difficile spores from the clinical setting requires stringent application of infection control procedures including the use of hard-surface disinfectants. A unique combination of sodium taurocholate together with amino acids has been reported as an alternative approach to potentially eliminating spores of C. difficile by increasing their sensitivity to common disinfec...

Background: NAP1/027 Clostridium difficile infection (CDI) has rarely been reported in China. Objectives: The objective of this study was to strengthen the understanding risk factors and outcomes CDI. Methods: A single-center, retrospective, case-control (1: 3) performed identify specific CDI using a group patients with (n = 20) age-matched control non-NAP1/027 60) within June 2018 August 2021....

We characterized 670 Clostridium difficile isolates collected from patients in 84 hospitals in Germany in 2008. PCR ribotyping showed high prevalence of ribotype 001 and restricted dissemination of ribotype 027 strains. Fluoroquinolone resistance and associated gyrase mutations were frequent in various ribotypes, but no resistance to metronidazole or vancomycin was noted.