The incidence and possible causes of paradoxical hypertension were evaluated in eight children who underwent balloon dilatation and seven children who underwent surgical repair of coarctation of the aorta. Both procedures resulted in a significant reduction in the coarctation gradient. Both systolic and diastolic blood pressures increased in the surgical group after repair, whereas systolic pre...

BACKGROUND Previous studies have suggested that any benefits of folic acid-based therapy to lower serum homocysteine in prevention of cardiovascular events might be offset by concomitant use of antiplatelet therapy. We aimed to establish whether there is an interaction between antiplatelet therapy and the effects of folic acid-based homocysteine-lowering therapy on major vascular events in pati...

The incidence and possible causes of paradoxical hypertension were evaluated in eight children who underwent balloon dilatation and seven children who underwent surgical repair of coarctation of the aorta. Both procedures resulted in a significant reduction in the coarctation gradient. Both systolic and diastolic blood pressures increased in the surgical group after repair, whereas systolic pre...

Idiosyncratic drug hepatotoxicity is a major problem in pharmaceutical development due to poor prediction capability of standard preclinical toxicity assessments and limited knowledge of its underlying mechanisms. Findings in animal models have shown that adverse effects of numerous drugs with idiosyncratic hepatotoxicity in humans can be reproduced in the presence of coincident inflammatory cy...

We compute an asymptotic estimate of a lower bound of the number of k-convex polyominoes of semiperimeter p. This approximation can be written as μ(k)p4p where μ(k) is a rational fraction of k which up to μ(k) is the asymptotics of convex polyominoes. A polyomino is a connected set of unit square cells drawn in the plane Z × Z [7]. The size of a polyomino is the number of its cells. A central p...

The incidence and possible causes of paradoxical hypertension were evaluated in eight children who underwent balloon dilatation and seven children who underwent surgical repair of coarctation of the aorta. Both procedures resulted in a significant reduction in the coarctation gradient. Both systolic and diastolic blood pressures increased in the surgical group after repair, whereas systolic pre...

ELECTRICAL ABNORMALITIES within the heart can often result in the development of arrhythmias that may further progress into sudden cardiac death; often the origins of these developments remain largely unknown. Atrial fibrillation, which is one of the most common type of heart arrhythmia, affects an estimated 3–6 million people within the United States (Center for Disease Control). Arrhythmic ev...

Given the integers 1,, k,,1 2 , k 2 , r, which satisfy the condition 1,, 1 2 > r> k,, k 2 > 0, we define m = N(1,, k, ; 1 2 , k 2 ; r) as the smallest integer with the following property : if S is a set containing m points and the r-subsets of S are partitioned arbitrarily into two classes, then for i = 1 or 2 there exists an l i subset of S each of whose ki-subsets lies in some r-subset of the...

SINCE THE FIRST DESCRIPTION of ischemic postconditioning in an in vivo dog model of ischemia-reperfusion (I/R) injury by Dr. Zhi-Qing Zhao and colleagues of Emory University in a seminal paper published in the American Journal of Physiology-Heart and Circulatory Physiology in 2003 (27), this cardioprotective modality has been confirmed in many mammalian species including humans (20) and mice (1...

A taxia-telangiectasia mutated (ATM) kinase, the mutation of which causes the autosomal recessive disease ataxiatelangiectasia, plays an essential role in the maintenance of genome stability (reviewed in ref. 1). ATM (a serine/threonine protein kinase) senses DNA double-strand breaks and phosphorylates several key proteins to initiate the DNA damage response, leading to cell cycle arrest, DNA r...