Recruitment rate of clinical trials in cancer patients is pretty low in China. Little is known about factors influencing trial recruitment in Chinese cancer patients. The aim of present study is to evaluate the barriers and facilitators to participation in clinical trials among lymphoma patients in China.From December 2014 to August 2015, the survey was carried out in the Department of Medical ...

To describe the clinical and biologic features of pediatric acute megakaryoblastic leukemia (AMKL) and to identify prognostic factors, experience at St Jude Children’s Research Hospital was reviewed. Of 281 patients with acute myeloid leukemia treated over a 14-year period, 41 (14.6%) had a diagnosis of AMKL. Six patients had Down syndrome and AMKL, 6 had secondary AMKL, and 29 had de novo AMKL...

Purpose: The present study aimed to confirm by classical and molecular laboratory methods hospitalassociated outbreaks due to virulent Klebsiella pneumoniae strains. Methods: Eighty three Klebsiella pneumoniae strains isolated from new-born patients, adults and hospital environment and devices in five hospital units, were analyzed for resistance to antibiotics, including last generation cephalo...

The major histocompatibility complex class I chain-related gene A (MICA) is involved in immune responses of both nature killer (NK) cells and subsets of T cells with its receptor NKG2D. MICA is highly polymorphic in sequence which leads to MICA protein variants with distinct features. Specific polymorphisms of MICA have been associated with inflammatory diseases, including ankylosing spondyliti...

To describe the clinical and biologic features of pediatric acute megakaryoblastic leukemia (AMKL) and to identify prognostic factors, experience at St Jude Children's Research Hospital was reviewed. Of 281 patients with acute myeloid leukemia treated over a 14-year period, 41 (14.6%) had a diagnosis of AMKL. Six patients had Down syndrome and AMKL, 6 had secondary AMKL, and 29 had de novo AMKL...

In the version of article originally published in volume 63, issue 4, 2020 Sci China Mater (2020, 63(4): 629-643, https://doi.org/10.1007/s40843-019-1217-4 ), grant number for National Natural Science Foundation (31300788) was incorrect. The corrected is 31670981.

Systemic lupus erythematosus (SLE) is a devastating systemic inflammatory disease, with prominent female bias. Recent literature suggests the OX40/OX40L costimulatory pathway may play an important role in development of SLE. GWAS have identified TNFSF4 (OX40L) as SLE susceptibility locus. OX40L stimulation T cells through OX40 receptor has been shown to promote follicular helper (Tfh) phenotype...