Thulin, E. 2017. Mechanisms and Dynamics of Mecillinam Resistance in Escherichia coli. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1375. 69 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0090-0. The introduction of antibiotics in healthcare is one of the most important medical achievements with regard to reducing human morbidity and mortal...

Objective: To investigate whether or not reconstruction of the medial cortex in subtrochanteric fracture can reduce the risks of internal fixation failure, fracture malunion, and nonunion. Subjects and Methods: Between 2005 and 2008, 46 patients with subtrochanteric fracture were treated with intramedullary nailing and followed up. The average age was 42 years. According to the Seinsheimer clas...

This comment points out some papers published before a recently published paper by Vitetta and Taylor. These early papers have dealt with the general problem of maximumlikelihood sequence estimation of coded/uncoded phase-shift keying (PSK) and quadrature amplitude modulation (QAM) signals in correlated Rician and Rayleigh-fading channels. These publications did not assume use of interleaving o...

BACKGROUND Greece was one of the countries hit the hardest by the 2008 financial crisis in Europe. Yet, evidence on the effect of the crisis on total and cause-specific mortality remains unclear. We explored whether the economic crisis affected the trend of overall and cause-specific mortality rates. METHODS We used regional panel data from the Hellenic Statistical Authority to assess mortali...

Drug-metabolizing enzymes and drug transporters are key determinants of the pharmacokinetics and pharmacodynamics of many antineoplastic agents. Metabolism and transport influence the cytotoxic effects of antineoplastic agents in target tumor cells and normal host tissues. This article summarizes several state-of-theart approaches to enhancing the effectiveness and safety of cancer therapy base...

Capecitabine (Xeloda; CAP) is a recently developed oral antineoplastic prodrug of 5-fluorouracil (5-FU) with enhanced tumor selectivity. Previous studies have shown that CAP activation follows a pathway with three enzymatic steps and two intermediary metabolites, 5 -deoxy-5-fluorocytidine (5 -DFCR) and 5 -deoxy-5-fluorouridine (5 -DFUR), to form 5-FU preferentially in tumor tissues. In the pres...

Class III alcohol dehydrogenase (ADH3), also termed formaldehyde dehydrogenase or S-nitrosoglutathione reductase, plays a critical role in the enzymatic oxidation of formaldehyde and reduction of nitrosothiols that regulate bronchial tone. Considering reported associations between formaldehyde vapor exposure and childhood asthma risk, and thus potential involvement of ADH3, we reviewed the onto...

The metabolism and excretion of [C]sitagliptin, an orally active, potent and selective dipeptidyl peptidase 4 inhibitor, were investigated in humans after a single oral dose of 83 mg/193 Ci. Urine, feces, and plasma were collected at regular intervals for up to 7 days. The primary route of excretion of radioactivity was via the kidneys, with a mean value of 87% of the administered dose recovere...

The art and science of speech recognition have been advanced to the state where it is now possible to communicate reliably with a computer by speaking to it in a disciplined manner using a vocabulary of moderate size. It is the purpose of this paper to outline two aspects of speech-recognition research. First, we discuss word recognition as a classical pattern-recognition problem and show how s...

[(3R)-4-(4-Chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4tetrahydrocyclopentaindol-3-yl]acetic acid (MK-0524) is a potent orally active human prostaglandin D2 receptor 1 antagonist that is currently under development for the prevention of niacin-induced flushing. The metabolism and excretion of [C]MK-0524 in humans were investigated in six healthy human volunteers following a single p.o. dos...