A genuine triterpenoid saponin, platyconic acid A (1) was isolated from the roots extract of Platycodon grandiflorum, together with five known saponins: deapioplatycoside E (2), platycoside E (3), platycodin D(3) (4), platycodin D(2) (5) and platycodin D (6). The structure of 1 was determined on the basis of spectral analysis and chemical evidence.

BACKGROUND Anthracyclines, alone or in combination with other drugs, are among the most effective chemotherapeutic agents to treat breast cancer both in the adjuvant and neoadjuvant setting. Unfortunately, anthracycline-associated dose-dependent cardiotoxicity is a limiting factor in clinical use. Extensive efforts have been devoted to identifying strategies to prevent anthracycline-induced car...

Resistance to chemotherapy and recurrence are major hurdles treating hormone receptor-negative breast cancer. The crude extract natural products obtained from medicinal plants believed be multitargeted possess less toxicity as compared synthetic compounds. aerial parts roots of Moricandia sinaica (Boiss.) Boiss were used prepare the extracts in solvents different polarities. Human cancer cell l...

Abstract The use of organic waste as components substrate to produce fruit plantlets provides alternative materials, easily available and low cost. aim this work was evaluate the effect biofertilization with cow urine on growth cupuaçu plants (Theobroma grandiflorum) in an production system. A factorial experiment conducted a completely randomized design 12 replications including four types sub...

BACKGROUND Premenstrual Syndrome (PMS) is a common problem in women. Zataria multiflora Boiss is a valuable plant. This herbal plant has been used in different conditions. OBJECTIVES The study was performed to investigate the effects of Zataria multiflora Boiss to control PMS symptoms. MATERIALS AND METHODS This study was a double-blinded, prospective randomized trial. The study population ...