Coenzyme Q10 (Q10) is present in the circulation mainly in its reduced form (ubiquinol-10; UL10), but oxidizes quickly ex vivo to ubiquinone-10 (UN10). Therefore, native UL10:UN10 ratios, used as markers of redox status and disease risk, are difficult to measure. We established an RP-(U)HPLC method with coulometric detection to measure natively circulating UL10 and UN10 concentrations by adding...

Mitochondrial dysfunction and oxidative stress are the major events that lead to the formation of mitochondrial permeability transition pore (mPTP) during glutamate-induced cytotoxicity and cell death. Coenzyme Q10 (CoQ10) has widely been used for the treatment of mitochondrial disorders and neurodegenerative diseases. Comparing to traditional lipid-soluble CoQ10, water soluble CoQ10 (Ubisol-Q1...

Most chrysanthemum cultivars are self-incompatible, so it is very difficult to create pure lines that are important in chrysanthemum breeding and theoretical studies. In our previous study, we obtained a self-compatible chrysanthemum cultivar and its self-pollinated seed set was 56.50%. It was interesting that the seed set of its ten progenies ranged from 0% to 37.23%. Examination of the factor...

UNLABELLED Recent studies have shown that the formation of myringosclerosis could be reduced by the application of antioxidant enzymes and elements. OBJECTIVE The aim of this study was to investigate the effectiveness of coenzyme Q10 on the prevention of experimentally induced myringosclerosis. METHOD Forty-eight healthy female wistar albino rats were bilaterally myringotomized and divided ...

Numerous studies have demonstrated exceptionally high temperature sensitivity of the beneath-snow respiratory flux in cold-winter ecosystems. The most common, but still untested, explanation for this high sensitivity is a physical one based on the observation that water availability in soils increases exponentially as soils warm from -3 to 0 C. Here, we present evidence for a biological hypothe...

We tested whether the reduction of metabolic rate (MR) in hibernating Cercartetus nanus (Marsupialia, 36 g) is better explained by the reduction of body temperature (Tb), the differential (ΔT) between Tb and air temperature (Ta), or thermal conductance (C). Above the critical Ta during torpor (Ttc) of 4.8 ± 0.7°C, where the Tb was not regulated, the steady-state MR was an exponential function o...

Temperature sensitivity of soil organic carbon (SOC) mineralization (i.e., Q10) determines how strong the feedback from global warming may be on the atmospheric CO2 concentration; thus, understanding the factors influencing the interannual variation in Q10 is important for accurately estimating local soil carbon cycle. In situ SOC mineralization rate was measured using an automated CO2 flux sys...

Objective To evaluate the effect of ubiquinone (Coenzyme Q10) and combined antioxidant therapy (CAT) on oxidative stress markers in non-proliferative diabetic retinopathy (NPDR) under clinical management. Study design In a randomized, double-blind, phase IIa, placebo-controlled, clinical trial, three study groups were formed and administered medications as follows: Group 1, Coenzyme Q10; Group ...

The safety profile of Coenzyme Q10 (Kaneka Q10) at high doses for healthy subjects was assessed in a double-blind, randomized, placebo-controlled study. Kaneka Q10 in capsule form was taken for 4 weeks at doses of 300, 600, and 900 mg/day by a total of eighty-eight adult volunteers. No serious adverse events were observed in any group. Adverse events were reported in 16 volunteers with placebo,...