Members of the Bcl-2 family play a major role in the pathobiology of head and neck cancer. We have shown that Bcl-2 orchestrates a cross talk between tumor cells and endothelial cells that have a direct effect on the progression of head and neck squamous cell carcinoma (HNSCC). Notably, Bcl-2 is significantly up-regulated in the tumor-associated endothelial cells compared with the endothelial c...

Time Warp (TW), although generally accepted as a potentially effective parallel and distributed simulation mechanism for timed Petri nets, can reveal deficiencies in certain model domains. Particularly, the unlimited optimism underlying TW can lead to excessive aggressiveness in memory consumption due to saving state histories, and waste of CPU cycles due to overoptimistically progressing simul...

The objective of this longitudinal retrospective study was to evaluate differences of the fetal growth and fetal organ growth among singleton small for gestational age (S-SGA), singleton appropriate for gestational age (S-AGA), twin (Tw-AGA), and triplet (Tri-AGA) infants. Ultrasonographic examinations were performed on 35 S-AGA, 18 S-SGA, 52 Tw-AGA and 12 Tri-AGA fetuses. Circumferences of hea...

This paper describes an object-oriented Time Warp (TW) mechanism which supports general parallel simulation on a distributed, possibly heterogeneous, computing environment. As a significant application of the developed TW, a simulation model adequate for large personal communication services (PCS) networks is proposed and its performance results given. Special attention is paid to such TW criti...

We give asymptotically exact values for the treewidth tw(G) of a random geometric graph G ∈ G(n, r) in [0, √ n]. More precisely, let rc denote the threshold radius for the appearance of the giant component in G(n, r). We then show that for any constant 0 < r < rc, tw(G) = Θ( logn log logn ), and for c being sufficiently large, and r = r(n) ≥ c, tw(G) = Θ(r √ n). Our proofs show that for the cor...

IgA nephropathy (IgAN) is characterized by high serum IgA levels and IgA deposition in the renal mesangium. Recent research has indicated that pathogenic IgA may originate from affected tonsils, where present enhancement of IgA production by IgA class switching and immuno-activation. Tripterygium Wilfordii (TW) was found to be especially effective in IgAN by its' immunosuppression effect. Given...

A polyhedral study of the asymmetric travelling salesman problem with time windows Abstract The asymmetric travelling salesman problem with time windows (ATSP-TW) is a basic model for scheduling and routing applications. In this paper we present a formulation of the problem involving only 0/1-variables associated with the arcs of the underlying digraph. This has the advantage of avoiding additi...

BACKGROUND Black men who have sex with men (MSM), and Transwomen (TW) shoulder disproportionate burden of HIV. However, they are unrepresented in HIV vaccine trials. We investigated the perceptions of that factors associated with HIV vaccine trials participation among Black MSM and TW in New York. METHODS Self-administered online questionnaires were administered to 18-29 years of NYC resident...

We investigated the properties of pulse propagation on nonlinear traveling-wave field effect transistors (TW-FET) to develop a method for amplifying short electrical pulses. TW-FETs are a special type of FET whose electrodes are employed not only as electrical contacts but also as transmission lines. Due to the presence of electromagnetic couplings between the gate and drain lines, two differen...