نتایج جستجو برای: کشف mirna
تعداد نتایج: 32753 فیلتر نتایج به سال:
background: micrornas (mirna) are small non-coding rnas that have a distinguished role in post- transcriptional gene expression. it’s estimated that 10-30% of human mrnas are regulated by mirnas. many mirnas profiles change during normal erythropoiesis in which some of them are stage specific.mir-155 was downregulated 200 fold in erythropoiesis. materials and methods: k562cells were grown in rp...
objective: micro-rnas (mirnas) are a class of posttranscriptional regulators that play crucial roles in various biological processes. emerging evidence suggests a direct link between mirnas and development of several diseases including type 2 diabetes (t2d). in this study, we aimed to investigate the effect of predicted mirna and target genes on insulin resistance. materials and methods: this e...
Introduction: Epileptic neurological disorder, which is controlled with medications such as sodium valproate (one of the treatment priorities for the patients with epilepsy). Polycystic ovary syndrome (PCOS) is one of complication of sodium valproate. Ovulation in PCOs Patients is disrupted, resulting in serious complications, including endometrial hyperplasia with typical and atypical forms, i...
کلزا (Brassica napus) از مهم‌ترین گیاهان روغنی در سطح جهان است که علاوه بر دارا بودن ذخایر غنی اسیدهای چرب، حاوی پروتئین نیز می‌باشد. تنش سرما از عوامل محدودکننده رشد این گیاه است که می‌تواند منجر به تغییرات وسیعی به لحاظ مولکولی در درون گیاه شود. در پژوهش حاضر، به منظور بررسی ارتباط بین مولکول های miRNA، تنش سرما، اسیدهای چرب و لیپیدها، مولکول‌های miRNA با اسامی bna-miR164a، bra-miR5712، bra-...
MicroRNAs (miRNAs) are short, endogenous non-coding RNAs that function as guide molecules to regulate transcription of their target messenger RNAs. Several methods including low-density qPCR arrays are being increasingly used to profile the expression of these molecules in a variety of different biological conditions. Reliable analysis of expression profiles demands removal of technical variati...
Background: Over the past 15 years, significant insights have been gained into the roles of miRNAs in cancer. In various cancers, miRNAs can act as oncogenes, tumor suppressors, or control the metastasis process by modulating the expression of numerous target genes. This study is aimed at determining molecular network of miRNA-mRNA regulating lung cancer invasion, by bioinformatics approaches. ...
Objective(s): Vascular calcification is one the major characteristics in patients with various types of chronic inflammatory disorders. MiRNAs have been shown to be involved in many normal biological functions as well as diseases; however, their role in vascular calcification has not received much attention. Materials and Methods: In the current study, we built a vascular calcification rat mode...
Background: Colorectal cancer is the third most common cancer in the world. Non-coding RNA especially miRNAs have important regulatory roles in cancer. miRNAs are small non coding RNA 21-23 nucleotides long which have different levels of expression between tumors and normal tissues. This study was designed to compare expression level of miRNA-21 between Iranian population colorectal cancer tiss...
BACKGROUND The aim of this study was to investigate the diagnostic and prognostic value of microRNA (miRNA)-21, miRNA-23a, and miRNA-125b in Burkitt lymphoma (BL) in children. MATERIAL AND METHODS We recruited 41 children with BL for the case group, 56 children with lymph node inflammation for the positive control group, and 60 healthy children for the negative control group. Real-time fluoresc...
زمینه و هدف: mirnaها دسته ای از rna های غیر کدشونده هستند که در فرایندهای مختلف سلولی ایفای نقش می کنند. اخیراً تغییر بیان این مولکول ها در بیماری های بسیاری گزارش شده است. متأسفانه بیماری مالتیپل اسکلروزیس امروزه به عنوان یک بیماری خود ایمن در ایران رو به افزایش است. سلول های th17 مهم ترین سلول ها در این بیماری می باشند. در این مطالعه ما به دنبال نقش احتمالی mirna های mir-142، mir-146a و mir-1...
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