MicroRNAs (miRNAs) are short nucleotide sequences that form a typical hairpin structure which is recognized by a complex enzyme machinery. It ultimately leads to the incorporation of 18-24 nt long mature miRNAs into RISC where they act as recognition keys to aid in regulation of target mRNAs. It is involved to determine miRNAs experimentally and, therefore, machine learning is used to complemen...

Given a set of spatial objects, our task is to assign all the objects to the minimum number of service sites and to find the regions for building these service sites. Each service site has a coverage region (i.e., an area of service) and a capacity (i.e., a maximum number of objects it can serve, called k-constraint). The service sites can provide service for objects located within the coverage...

Recent functional neuroimaging studies have revealed that occipital or visual cortical areas in individuals blinded in o_r around birth are metabolically active during tactile, auditory and cognitive stimulation. These findings suggest that in the early blind (EB) the areas that are normally engaged by visual stimulation process non-visual information (a phenomenon referred to as cross-modal re...

We previously showed that nordihydroguaiaretic acid (NDGA) and other antioxidants inhibit the resumption of meiosis in oocyte-cumulus complexes (OCC) and denuded oocytes (DO). Because NDGA is well known to be an inhibitor of lipoxygenases (LOX), we assessed whether other LOX inhibitors influence spontaneous germinal vesicle breakdown (GVBD) in OCC and DO. Spontaneous GVBD in rat OCC obtained fr...

Background: In contrast to pharyngo-laryngeal cancer, definitive radiation-chemotherapy of advanced oral cavity cancer (OCC) results in inferior disease control rates. Surgery in combination with radiation +/concomitant chemotherapy is therefore the treatment of choice for squamous cell OCC stages >/=pT1-2pN0-1. Modern intensity modulated radiation techniques (IMRT) allow more conformal dose di...

There is an ever-increasing demand for more complex transactions and higher throughputs in transaction processing systems leading to higher degrees of transaction concurrency and, hence, higher data contention. The conventional two-phase locking (2PL) Concurrency Control (CC) method may, therefore, restrict system throughput to levels inconsistent with the available processing capacity. This is...

Previous results suggest that extracellular dopamine (DA) in the rat cerebral cortex originates from dopaminergic and noradrenergic terminals. To further clarify this issue, dialysate DA, dihydroxyphenylacetic acid (DOPAC) and noradrenaline (NA) were measured both in the medial prefrontal cortex (mPFC) and in the occipital cortex (OCC), with dense and scarce dopaminergic projections, respective...

We present new algorithms for the problem of multiple string matching of gapped patterns, where a gapped pattern is a sequence of strings such that there is a gap of fixed length between each two consecutive strings. The problem has applications in the discovery of transcription factor binding sites in DNA sequences when using generalized versions of the Position Weight Matrix model to describe...