نتایج جستجو برای: ژن stk11

تعداد نتایج: 16599  

Journal: :JAMA 2005
Kevin Sweet Joseph Willis Xiao-Ping Zhou Carol Gallione Takeshi Sawada Pia Alhopuro Sok Kean Khoo Attila Patocs Cossette Martin Scott Bridgeman John Heinz Robert Pilarski Rainer Lehtonen Thomas W Prior Thierry Frebourg Bin Tean Teh Douglas A Marchuk Lauri A Aaltonen Charis Eng

CONTEXT Significant proportions of patients with hamartomatous polyposis or with hyperplastic/mixed polyposis remain without specific clinical and molecular diagnosis or present atypically. Assigning a syndromic diagnosis is important because it guides management, especially surveillance and prophylactic surgery. OBJECTIVE To systematically classify patients with unexplained hamartomatous or ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Jitu W George Amanda L Patterson Pradeep S Tanwar André Kajdacsy-Balla Gail S Prins Jose M Teixeira

Nearly all older men will experience lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH), the etiology of which is not well understood. We have generated Stk11CKO mice by conditional deletion of the liver kinase B1 (LKB1) tumor suppressor gene, Stk11 (serine threonine kinase 11), in the fetal Müllerian duct mesenchyme (MDM), the caudal remnant of which is thought to ...

2011
Yme U. van der Velden Anna-Pavlina G. Haramis

The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy‐metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue‐specific and context‐dependent effectors.

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