نتایج جستجو برای: ژن gpr54
تعداد نتایج: 16015 فیلتر نتایج به سال:
Kisspeptin is the peptide product of the KiSS-1 gene and the endogenous agonist for the GPR54 receptor. Recent evidence suggests the kisspeptin/GPR54 system is a key regulator of the reproductive system. We examined the effect of intracerebroventricular (i.c.v.) and peripheral administration of the active kisspeptin fragment, kisspeptin-10, on circulating gonadotrophins and total testosterone l...
Cancer disease is the second leading cause of death in the world and one of the main fields of medical research. Although there is now a greater understanding of biological mechanisms of uncontrolled cell growth, invasiveness and metastasization, the multistep process of cancer development and evolution is still incompletely understood. The inhibition of molecules activated in cancer metastasiz...
Genetic and environmental factors are implicated in the timing of puberty (1). Human studies have shown a relationship between body mass index or body fat, dietary and physical activity with the timing of puberty (2, 3, 4). More recently a G-protein coupled receptor, GPR54 and its ligand Kisspeptin have been identified as important signals in pubertal induction (5). The role of leptin in the pu...
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