نتایج جستجو برای: ژن fto

تعداد نتایج: 17747  

2017
Yu Kang Fang Liu Yao Liu

Previous studies have examined the association between the fat mass and obesity-associated (FTO) gene variant and risk of cancer in diverse populations. However, the results have been inconsistent. PubMed and Embase databases were searched for the eligible publications in English language by July, 2016. The associations of FTO variants with cancer risk were estimated by calculating the pooled o...

2011
Yan Guo Hui Liu Tie-Lin Yang Siyang M. Li Siyuan K. Li Qing Tian Yong-Jun Liu Hong-Wen Deng

Obesity and osteoporosis are closely correlated genetically. FTO gene has been consistently identified to be associated with obesity phenotypes. A recent study reported that the mice lacking Fto could result in lower bone mineral density (BMD). Thus, we hypothesize that the FTO gene might be also important for osteoporosis phenotypes. To test for such a hypothesis, we performed an association a...

ژورنال: :علوم و مهندسی سطح ایران 0

در این مقاله روشی سریع و بهینه برای کاهش زبری سطحی قلع اکسید آلاییده شده با فلور (fto) با استفاده از نانوذرات موجود در خمیر دندان ارایه شده است. پایداری فیزیکی و شیمیایی بالای fto نسبت به دیگر رساناهای شفاف اکسیدی (tco) همانند ایندیوم قلع اکسید (ito)  باعث می شود که از آن ها در قطعات الکترواپتیکی استفاده شود. اما به دلیل بالا بودن ضخامت آن نسبت به ito و شرایط ساخت آن معمولا زبری زیادتری نسبت به...

Journal: :PLoS ONE 2009
Laura Johnson Cornelia H. M. van Jaarsveld Pauline M. Emmett Imogen S. Rogers Andy R. Ness Andrew T. Hattersley Nicholas J. Timpson George Davey Smith Susan A. Jebb

BACKGROUND Dietary energy density (DED) does not have a simple linear relationship to fat mass in children, which suggests that some children are more susceptible than others to the effects of DED. Children with the FTO (rs9939609) variant that increases the risk of obesity may have a higher susceptibility to the effects of DED because their internal appetite control system is compromised. We t...

2014
Luca Carnevali Gallia Graiani Stefano Rossi Mumna Al Banchaabouchi Emilio Macchi Federico Quaini Nadia Rosenthal Andrea Sgoifo

In humans, variants of the fat mass and obesity associated (FTO) gene have recently been associated with obesity. However, the physiological function of FTO is not well defined. Previous investigations in mice have linked FTO deficiency to growth retardation, loss of white adipose tissue, increased energy metabolism and enhanced systemic sympathetic activation. In this study we investigated for...

Journal: :Neurobiology of aging 2011
Christian Benedict Josefin A Jacobsson Elina Rönnemaa Markus Sällman-Almén Samantha Brooks Bernd Schultes Robert Fredriksson Lars Lannfelt Lena Kilander Helgi B Schiöth

Humans carrying the prevalent rs9939609 A allele of the fat mass and obesity-associated (FTO) gene are more susceptible to developing obesity than noncarries. Recently, polymorphisms in the FTO gene of elderly subjects have also been linked to a reduced volume in the frontal lobe as well as increased risk for incident Alzheimer disease. However, so far there is no evidence directly linking the ...

2015
Cindy Thron Payam Akhyari Erhard Godehardt Artur Lichtenberg Ulrich Rüther Stefanie Seehaus Amanda Ewart Toland

BACKGROUND Single nucleotide polymorphisms (SNPs) within the Fat mass and obesity associated (FTO) gene have been linked with increased body weight. However, the data on an association of FTO with cardiovascular diseases remains conflicting. Therefore, we ascertained whether FTO is associated with aortic valve stenosis (AVS), one of the most frequent cardiovascular diseases in the Western world...

Journal: :Journal of medical Internet research 2016
Cyril F M Marsaux Carlos Celis-Morales Katherine M Livingstone Rosalind Fallaize Silvia Kolossa Jacqueline Hallmann Rodrigo San-Cristobal Santiago Navas-Carretero Clare B O'Donovan Clara Woolhead Hannah Forster George Moschonis Christina-Paulina Lambrinou Agnieszka Surwillo Magdalena Godlewska Jettie Hoonhout Annelies Goris Anna L Macready Marianne C Walsh Eileen R Gibney Lorraine Brennan Yannis Manios Iwona Traczyk Christian A Drevon Julie A Lovegrove J Alfredo Martinez Hannelore Daniel Michael J Gibney John C Mathers Wim H M Saris

BACKGROUND There is evidence that physical activity (PA) can attenuate the influence of the fat mass- and obesity-associated (FTO) genotype on the risk to develop obesity. However, whether providing personalized information on FTO genotype leads to changes in PA is unknown. OBJECTIVE The purpose of this study was to determine if disclosing FTO risk had an impact on change in PA following a 6-...

Journal: :Archives of internal medicine 2008
Evadnie Rampersaud Braxton D Mitchell Toni I Pollin Mao Fu Haiqing Shen Jeffery R O'Connell Julie L Ducharme Scott Hines Paul Sack Rosalie Naglieri Alan R Shuldiner Soren Snitker

BACKGROUND Common FTO (fat mass and obesity associated) gene variants have recently been associated with body mass index (BMI) and obesity in several large studies. The role of lifestyle factors (such as physical activity) in those with an underlying FTO genetic predisposition is unknown. METHODS To determine if FTO variants are associated with BMI in Old Order Amish (OOA) individuals, and to...

Journal: :Diabetes 2008
Rachel M Freathy Nicholas J Timpson Debbie A Lawlor Anneli Pouta Yoav Ben-Shlomo Aimo Ruokonen Shah Ebrahim Beverley Shields Eleftheria Zeggini Michael N Weedon Cecilia M Lindgren Hana Lango David Melzer Luigi Ferrucci Giuseppe Paolisso Matthew J Neville Fredrik Karpe Colin N A Palmer Andrew D Morris Paul Elliott Marjo-Riitta Jarvelin George Davey Smith Mark I McCarthy Andrew T Hattersley Timothy M Frayling

OBJECTIVE Common variation in the FTO gene is associated with BMI and type 2 diabetes. Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, and triglycerides. We aimed to test whether FTO genotype is associated with variation in these metabolic traits. RESEARCH DESIGN AND METHODS We tested the association between FTO genotype and 10 metabolic traits using...

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