UNLABELLED Objective : The objective of the study was to observe the antimicrobial resistance of AmpC β-lactamase producing E. coli. METHODS Six hundred and seventy E. coli were isolated from 20,257 various pathological samples collected from The Children's Hospital and Institute of Child Health, Lahore, Pakistan. The isolates showed resistance to ceftazidime which were further examined for A...

background :   ampc β-lactamases are important cephalosporinases chromosomally encoded in many of enterobacteriaceae and a few other organisms where they mediate resistance to cephalothin, cefazolin, cefoxitin and penicillins. the six different families of plasmid-mediated ampc β-lactamases have been described, but no phenotypic test can discriminate among them. ampc multiplex pcr has been succ...

Acinetobacter baumannii is a troublesome opportunistic pathogen with a high capacity for clonal dissemination. We announce the establishment of a database for the ampC locus in A. baumannii, in which novel ampC alleles are differentiated based on the occurrence of ≥ 1 nucleotide change, regardless of whether it is silent or missense. The database is openly accessible at the pubmlst platform for...

Resistance to broad spectrum β lactams, mediated by extended spectrum beta lactamase (ESβL) and AmpC βL enzymes is fast spreading in Nigerian hospitals. Production of these enzymes has resulted in treatment failure especially if one of the second or third generation cephalosporins is used. A study was undertaken to determine the prevalence of each enzyme and coproduction of the two enzymes amon...

This paper deals with the energy management strategy (EMS) for an on-board semi-active hybrid energy storage system (HESS) composed of a Li-ion battery (LiB) and ultracapacitor (UC). Considering both the nonlinearity of the semi-active structure and driving condition uncertainty, while ensuring HESS operation within constraints, an adaptive model predictive control (AMPC) method is adopted to d...

Antimicrobial resistance (AMR) occurs when microorganisms fail to respond the therapeutic onslaught of antibiotics. Extended-spectrum beta-lactamase (ESBL) and AmpC enzymes are important AMR mechanisms that erode efficacy Here, we report on detection susceptibility ESBL- AmpC-producing bacteria from livestock poultry environments. Bacteriological molecular biology tools were used for isolation ...

BACKGROUND  AmpC β-lactamase-producing organisms are associated with significant morbidity and mortality. Induction of resistance to third-generation cephalosporins after exposure to these agents complicates treatment options and carbapenems are considered optimal therapy. The role of cefepime, however, remains unclear. Our objective was to compare clinical outcomes for patients receiving cefep...

BACKGROUND Pseudomonas aeruginosa is an important nosocomial pathogen characterized by its innate resistance to multiple antimicrobial agents. Plasmid-mediated drug resistance also occurs by the production of extended-spectrum β-lactamases (ESBL), metallo β-lactamases (MBL), and AmpC β-lactamases. Another important factor for establishment of chronic infections by P. aeruginosa is biofilm forma...

OBJECTIVES AmpC β-lactamases are classified as Amber Class C and Bush Group 1. AmpC β-lactamases can hydrolyze broad and extended-spectrum cephalosporins, and are not inhibited by β-lactamase inhibitors such as clavulanic acid. This study was conducted to identify DHA-23, a novel plasmid-mediated and inducible AmpC β-lactamase obtained from Enterobacteriaceae. METHODS A total of 210 carbapene...

The widespread use of β-lactam antibiotics has lead to the development of resistance to this group of antibiotics in bacterial pathogens due to various types of β lactamase production. Amongst the mechanisms of resistance to third generation cephalosporins, production of extended spectrum β-lactamases (ESBLs) and AmpC β lactamases is the most common1. Since both ESBL and AmpC β-lactamase are en...