BACKGROUND Childhood sexual abuse (CSA) seriously influences children's psychological status. This study aimed to investigate the relationship between CSA and the psychiatric disorders. METHODS An anonymous and retrospective questionnaire survey was carried out in 1307 college students (aged 18-25 years; 701 females, 606 males) to investigate the participants' CSA experience by means of a com...

Volume 99 Published by Foundation of Computer Science Indexed with Google Scholar, CiteSeer and CSA Technology Research Database, ProQuest Volume 98 Published by Foundation of Computer Science Indexed with Google Scholar, CiteSeer and CSA Technology Research Database, ProQuest Volume 97 Published by Foundation of Computer Science Indexed with Google Scholar, CiteSeer and CSA Technology Resear...

Volume 99 Published by Foundation of Computer Science Indexed with Google Scholar, CiteSeer and CSA Technology Research Database, ProQuest Volume 98 Published by Foundation of Computer Science Indexed with Google Scholar, CiteSeer and CSA Technology Research Database, ProQuest Volume 97 Published by Foundation of Computer Science Indexed with Google Scholar, CiteSeer and CSA Technology Resear...

Volume 99 Published by Foundation of Computer Science Indexed with Google Scholar, CiteSeer and CSA Technology Research Database, ProQuest Volume 98 Published by Foundation of Computer Science Indexed with Google Scholar, CiteSeer and CSA Technology Research Database, ProQuest Volume 97 Published by Foundation of Computer Science Indexed with Google Scholar, CiteSeer and CSA Technology Resear...

Child sexual abuse (CSA) is an important public health problem with long-standing neurobiological, developmental, and psychiatric abnormalities. The present review analyzes the long-term effects of CSA from a developmental, psychiatric morbidity, neurochemical and neurobiological perspective and then tries to posit a developmental neurobiological trajectory from CSA to the genesis of psychopath...

Binary complex formation between the immunosuppressive drug cyclosporin A (CsA) and cyclophilin 18 is the prerequisite for the ability of CsA to inhibit the protein phosphatase activity of calcineurin, a central mediator of antigen-receptor signaling. We show here that several CsA derivatives substituted in position 3 can inhibit calcineurin without prior formation of a complex with cyclophilin...

Cyclosporine A (CsA) use is associated with hypertension and reduced baroreceptor sensitivity (BRS), but the underlying mechanisms remain unresolved. In this study, we investigated whether CsA attenuation of BRS is 1) dependent on treatment regimen, and 2) causative of the pressor response. Furthermore, we investigated whether a reduction in plasma testosterone contributes to BRS attenuation ca...

Colony-stimulating activity (CSA) is essential for in vitro differentiation of bone marrow cells into colonies of granulocytes and mononuclear cells. While blood monocytes and macrophages are a major source of CSA, recent studies have indicated that CSA may be produced by lymphocytes responding to immunologic stimulation. Lymphocytes, purified from spleens and thymuses of mice by glass wool col...

Cyclosporin A (CsA) causes a number of clinically relevant drug-drug interactions (DDIs) by inhibiting OATP1B1 and OATP1B3. In the present study, long-lasting inhibitory effects of CsA on these transporters were examined in comparison to tacrolimus (TCR). OATP1B1- and OATP1B3-expressing HEK293T cells, OATP1B1-expressing MDCK II cells, and human hepatocytes were preincubated with CsA or TCR, and...

BACKGROUND The prevalence and characteristics of sleep-disordered breathing in patients with asymptomatic left ventricular (LV) dysfunction are unknown. Therefore, we evaluated the prevalence of sleep-disordered breathing in patients with LV dysfunction without overt heart failure and tested the hypothesis that sleep-disordered breathing is linked to greater hemodynamic and autonomic impairment...