نتایج جستجو برای: ژن اگزونوکلئاز1 exo1

تعداد نتایج: 16153  

Journal: :Cell 2011
Hans Hombauer Christopher S. Campbell Catherine E. Smith Arshad Desai Richard D. Kolodner

DNA mismatch repair (MMR) increases replication fidelity by eliminating mispaired bases resulting from replication errors. In Saccharomyces cerevisiae, mispairs are primarily detected by the Msh2-Msh6 complex and corrected following recruitment of the Mlh1-Pms1 complex. Here, we visualized functional fluorescent versions of Msh2-Msh6 and Mlh1-Pms1 in living cells. We found that the Msh2-Msh6 co...

2017
Aneta Kaniak-Golik Renata Kuberska Piotr Dzierzbicki Ewa Sledziewska-Gojska

Rad27/FEN1 nuclease that plays important roles in the maintenance of DNA stability in the nucleus has recently been shown to reside in mitochondria. Accordingly, it has been established that Rad27 deficiency causes increased mutagenesis, but decreased microsatellite instability and homologous recombination in mitochondria. Our current analysis of mutations leading to erythromycin resistance ind...

1997
DANIEL X. TISHKOFF ADRIENNE L. BOERGER PASCALE BERTRAND NICOLE FILOSI GRETCHEN M. GAIDA MICHAEL F. KANE RICHARD D. KOLODNER

A two-hybrid screen was used to identify Saccharomyces cerevisiae genes encoding proteins that interact with MSH2. One gene was found to encode a homologue of Schizosaccharomyces pombe EXO1, a double-stranded DNA-specific 5*–3* exonuclease. S. cerevisiae EXO1 interacted with both S. cerevisiae and human MSH2 in two-hybrid and coimmunoprecipitation experiments. exo1 mutants showed a mutator phen...

2013
Nicholas L Adkins Hengyao Niu Patrick Sung Craig L Peterson

DSBs, if not repaired properly, pose a serious threat to genome integrity. Improperly repaired DSBs can lead to loss of genetic material, to chromosomal duplications or translocations and to carcinogenesis1. The yeast Mre11–Rad50–Xrs2 (MRX) complex facilitates the recognition of DNA ends and commitment to repair by homologous recombination. Subsequently, the nucleolytic processing of the ends r...

Journal: :Proceedings of the National Academy of Sciences 2003

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