نتایج جستجو برای: ژنهای oct4 و nanog
تعداد نتایج: 764586 فیلتر نتایج به سال:
Embryonic stem cell (ESC) pluripotency is governed by a gene regulatory network centered on the transcription factors Oct4 and Nanog. To date, robust self-renewing ESC states have only been obtained through the chemical inhibition of signaling pathways or enforced transgene expression. Here, we show that ESCs with reduced Oct4 expression resulting from heterozygosity also exhibit a stabilized p...
مقدمه: استفاده از ترکیبات گیاهی بهعنوان سرکوبکننده سرطان، امروزه اهمیت زیادی پیدا کرده است. هدف از مطالعه حاضر بررسی تأثیر غلظتهای مختلف عصاره زعفران (Crocus sativus) بر بیان ژنهای OCT4، KLF، SOX2 ، NANOG و Nucleostemin در رده سلولی AGS (Gastric Adenocarcinoma) بود. مواد و روش ها: رده سلول سرطانی آدنوکارسینوم معده (AGS) از بانک سلولی انستیتو پاستور ...
مقدمه: از زمان اولین انجماد شیشه‌ای رویان موش در سال 1985، تلاش‌ها‌ی قابل توجهی برای توسعه و بهبود این تکنیک صورت گرفته است اما همچنان انجماد با اعمال آسیب‌های جدی بیوشیمیایی و کروموزومی بر روی رویان می‌تواند باعث تغییراتی در الگوی بیان ژنهای دخیل در تکوین و عملکرد، کاهش لانه‌گزینی و نهایتا مرگ رویان گردد. هدف از این مطالعه بررسی تاثیرات انجماد شیشه‌ای بر زنده‌مانی و رشد و بررسی بیان ژنهای تخ...
Article history: Received: .................. Accepted: ................... Available online: ........ ZJRMS 2015 Sep; X(X): XX-XX Background: Genes are involved in the control of stem cell self-renewal as a new class of molecular markers of cancer. In this study, the expression of Oct4, Nanog and Sox2 in cell lines MIA Paca-2, PA-TU-8902 and AsPC-1 and pancreatic cancer tissue were examined. M...
The cancer stem cell theory hypothesizes that cancer stem cells (CSCs), which possess self-renewal and other stem cell properties, are regarded as the cause of tumor formation, recurrence and metastasis. The isolation and identification of CSCs could help to develop novel therapeutic strategies specifically targeting CSCs. In this study, we enrich...
Self-renewal and pluripotency are two fundamental characteristics of embryonic stem cells (ESCs) and are controlled by diverse regulatory factors, including pluripotent factors, epigenetic regulators and microRNAs (miRNAs). Although histone methyltransferases are key epigenetic regulators, whether and how a histone methyltransferase forms a network with miRNAs and the core pluripotent factor sy...
Maternal gestational diabetes mellitus (GDM) has many adverse effects on the development of offspring. Aberrant DNA methylation is a potential mechanism associated with these effects. However, the effects of GDM on tooth development and the underlying mechanisms have not been thoroughly investigated. In the present study, a GDM rat model was established and incisor labial cervical loop tissue a...
Many of the structural and mechanistic requirements of oocyte-mediated nuclear reprogramming remain elusive. Previous accounts that transcriptional reprogramming of somatic nuclei in mouse zygotes may be complete in 24-36 hours, far more rapidly than in other reprogramming systems, raise the question of whether the mere exposure to the activated mouse ooplasm is sufficient to enact reprogrammin...
STUDY QUESTION What is the methylation status of the Nanog and Oct4 promoters in human gametes and ICSI embryos and is abnormal reprogramming of their methylation associated with developmental failure of ICSI embryos? SUMMARY ANSWER Developmental failure of human ICSI embryos is associated with high methylation of the Oct4 promoter. WHAT IS KNOWN ALREADY Nanog and Oct4 genes play critical r...
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