نتایج جستجو برای: پروتوپورفیرین ix

تعداد نتایج: 18979  

2015
Wei-Ju Huang Yung-Ming Jeng Hong-Shiee Lai Iok-U Fong Fang-Yu Bonnie Sheu Po-Lin Lai Ray-Hwang Yuan

Carbonic anhydrase IX (CA-IX), a hypoxia marker, correlates with tumor progression in a variety of human cancers. However, the role of CA-IX in hepatocellular carcinomas (HCCs) remains largely unknown. We examined the expression of 277 unifocal, resectable, primary HCC tumors using immunohistochemistry. The CA-IX protein was expressed in 110 of the 227 (48.5%) HCC tumors. The expression of CA-I...

Journal: :The Journal of biological chemistry 1993
J A Bristol B C Furie B Furie

Factor IX is synthesized in a precursor form with a propeptide that contains the gamma-carboxylation recognition site, an element which directs the post-translational gamma-carboxylation of adjacent glutamic acid residues. After protein synthesis, the propeptide is cleaved to yield the mature Factor IX. To study propeptide processing, anti-proFactor IX antibodies were prepared using a synthetic...

2002
EARL W. DAVIE

Bovine factor IX (Christmas factor) is a coagulation protein present in plasma in a precursor or inactive form. It is a glycoprotein (M, = 55,000) composed of a single polypeptide chain. Factor IX in the presence of calcium ions is converted to factor IX, by factor XI, (activated plasma thromboplastin antecedent) or a protease present in Russell’s viper venom. The activation of factor IX by the...

2002
John H. Hartwig

In resting platelets, the GPb-IX complex, the receptor for the von Willebrand factor (vWF), is linked to underlying actin filaments by actin-binding protein (ABP-280). Thrombin stimulation of human platelets leads to a decrease in the surface expression of the GPb-IX complex, which is redistributed from the platelet surface into the open canalicular system (OCS). Because the centralization of G...

Journal: :Blood 1997
H F Lin N Maeda O Smithies D L Straight D W Stafford

Coagulation factor IX deficiency causes hemophilia B in humans. We have used gene targeting to develop a coagulation factor IX-deficient (factor IX-knockout) mouse strain. Mouse embryonic stem (ES) cells were targeted by a socket-containing vector that replaces the promoter through exon 3 of the factor IX gene by neoDeltaHPRT, which is a functional neo gene plus a partially deleted hypoxanthine...

Journal: :Blood 1982
A H Goodall G Kemble D P O'Brien E Rawlings F Rotblat G C Russell G Janossy E G Tuddenham

A murine hybridoma clone is described that grows continuously in culture and produces a monoclonal antibody we have called Royal Free Monoclonal Antibody to factor IX No. 1 (RFF-IX/1). This has high affinity for a coagulation site on factor IX. RFF-IX/1 immobilised on sepharose can be used to deplete factor IX from normal human plasma. This immunoaffinity depleted plasma is indistinguishable fr...

Journal: :Journal of medicinal chemistry 2014
Janina Moeker Thomas S Peat Laurent F Bornaghi Daniela Vullo Claudiu T Supuran Sally-Ann Poulsen

Carbonic anhydrase IX (CA IX) is a target for hypoxic cancer therapies, and the discovery of CA IX selective ligands is imperative for the development of these agents. Primary sulfonamides are broad specificity inhibitors of CA enzymes, while secondary sulfonamides are generally poor CA inhibitors. However, saccharin, a cyclic secondary sulfonamide, has unusually good inhibition of CA IX (Ki = ...

Journal: :Photochemistry and photobiology 2010
Luciana Mercedes Pujol-Lereis Ana Massaldi Alejandro Rabossi Luis Alberto Quesada-Allué

Immature stages of Ceratitis capitata were tested as a model for hematoporphyrin IX (HP IX) phototoxicity. The lethal concentration 50 (LC(50)) of HP IX in the food was determined during postembryonic development until adult emergence as 0.173 mm (95% CI: 0.138-0.209). The corresponding HP IX LC(50) during the dispersal period alone was 0.536 mm (95% CI: 0.450-0.633). HP IX toxicity was compare...

2012
Bagna Bao Kevin Groves Jun Zhang Emma Handy Paul Kennedy Garry Cuneo Claudiu T. Supuran Wael Yared Milind Rajopadhye Jeffrey D. Peterson

Carbonic anhydrase IX (CA IX) is a transmembrane protein that has been shown to be greatly upregulated under conditions of hypoxia in many tumor cell lines. Tumor hypoxia is associated with impaired efficacy of cancer therapies making CA IX a valuable target for preclinical and diagnostic imaging. We have developed a quantitative in vivo optical imaging method for detection of CA IX as a marker...

Journal: :Blood 1995
J A López C Q Li S Weisman M Chambers

The monoclonal antibody SZ1 is of interest for two reasons: it was used to define complex formation between glycoprotein (GP) Ib and GP IX, and its epitope is likely to be identical to that recognized by most quinine- and quinidine-dependent autoantibodies that cause thrombocytopenia. To determine the location of the epitope for SZ1 within the GP Ib-IX complex (which consists of three subunits:...

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