نتایج جستجو برای: پروتئین nrf2

تعداد نتایج: 26324  

1997
Xi-Lin Chen Geraldine Dodd Suzanne Thomas Xiaolan Zhang Martin A. Wasserman Brad H. Rovin Charles Kunsch Dorothy M. Davis Xilin Chen

The antioxidant response element (ARE) is a transcriptional control element that mediates expression of a set of antioxidant proteins. Nrf2 is a transcription factor that activates ARE-containing genes. In endothelial cells, the ARE-mediated genes are upregulated by athero-protective laminar flow through a Nrf2-dependent mechanism. We tested the hypothesis that activation of ARE-regulated genes...

2018
Byung-Jin Jung Hwan-Sic Yoo Sooyoung Shin Young-Joon Park Sang-Min Jeon

Nuclear factor E2-related factor 2 (NRF2) plays an important role in redox metabolism and antioxidant defense. Under normal conditions, NRF2 proteins are maintained at very low levels because of their ubiquitination and proteasomal degradation via binding to the kelch‑like ECH associated protein 1 (KEAP1)-E3 ubiquitin ligase complex. However, oxidative and/or electrophilic stresses disrupt the ...

2018
Montserrat Rojo de la Vega Donna D. Zhang Georg T. Wondrak

Environmental exposure to solar ultraviolet (UV) radiation causes acute photodamage, premature aging, and skin cancer, attributable to UV-induced genotoxic, oxidative, and inflammatory stress. The transcription factor NRF2 [nuclear factor erythroid 2 (E2)-related factor 2] is the master regulator of the cellular antioxidant response protecting skin against various environmental stressors includ...

Journal: :Annals of the rheumatic diseases 2011
Christoph Jan Wruck Athanassios Fragoulis Agata Gurzynski Lars-Ove Brandenburg Yuet Wai Kan Kaimin Chan Joachim Hassenpflug Sandra Freitag-Wolf Deike Varoga Sebastian Lippross Thomas Pufe

OBJECTIVES Increasing evidence suggests that oxidative stress may play a key role in joint destruction due to rheumatoid arthritis (RA). The aim of this study was to elucidate the role of nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that maintains the cellular defence against oxidative stress, in RA. METHODS The activation status of Nrf2 was assessed in synovial ...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2014
John J Skoko Nobunao Wakabayashi Kentaro Noda Shoko Kimura Kimimasa Tobita Norihisa Shigemura Tadayuki Tsujita Masayuki Yamamoto Thomas W Kensler

The transcription factor Nrf2 (Nfe2l2 nuclear factor, erythroid 2-like 2) regulates gene expression directly, controlling pharmacological and toxicological responses. These processes may also be influenced by the structure of the hepatic vasculature, which distributes blood flow through compartmentalized microenvironments to maintain organismal stability. Castings of the hepatic portal vasculat...

2014
Takashi Ashino Haruyo Ohkubo-Morita Masayuki Yamamoto Takemi Yoshida Satoshi Numazawa

Cytochrome P450 gene expression is altered by various chemical compounds. In this study, we used nuclear factor erythroid 2-related factor 2 (Nrf2)-deficient (Nrf2(-⧸-)) mice to investigate the involvement of Nrf2 in Cyp2b10 and Cyp2a5 gene expression. Phorone, an Nrf2 activator, strongly increased Cyp2b10 and Cyp2a5 mRNA as well as Nrf2 target genes, including NAD(P)H-quinone oxidoreductase-1 ...

Journal: :FEBS letters 2012
Diána Papp Katalin Lenti Dezső Módos Dávid Fazekas Zoltán Dúl Dénes Türei László Földvári-Nagy Ruth Nussinov Péter Csermely Tamás Korcsmáros

NRF2 is a well-known, master transcription factor (TF) of oxidative and xenobiotic stress responses. Recent studies uncovered an even wider regulatory role of NRF2 influencing carcinogenesis, inflammation and neurodegeneration. Prompted by these advances here we present a systems-level resource for NRF2 interactome and regulome that includes 289 protein-protein, 7469 TF-DNA and 85 miRNA interac...

Journal: :International journal of clinical and experimental pathology 2015
Minghao Kong Jing Mao Bijun Luo Zonghao Qin

OBJECTIVE This study aimed to investigate the expression and role of Nrf2 in the acute lung injury (ALI) of mice. METHODS A total of 60 BABL/c mice were randomly divided into 2 groups: ALI group and control group. In ALI group, ALI was introduced by injection of LPS. Immunohistochemistry was performed to detect Nrf2 expression in the lung; Western blot assay was employed to detect the express...

Journal: :Antioxidants & redox signaling 2013
Shasha Tao Yi Zheng Alexandria Lau Melba C Jaramillo Binh T Chau R Clark Lantz Pak K Wong Georg T Wondrak Donna D Zhang

AIMS The NF-E2 p45-related factor 2 (Nrf2) signaling pathway regulates the cellular antioxidant response and activation of Nrf2 has recently been shown to limit tissue damage from exposure to environmental toxicants, including As(III). In an attempt to identify improved molecular agents for systemic protection against environmental insults, we have focused on the identification of novel medicin...

Journal: :The Journal of biological chemistry 2010
Jingbo Pi Laura Leung Peng Xue Weiping Wang Yongyong Hou Dianxin Liu Einav Yehuda-Shnaidman Candy Lee Jackie Lau Theodore W Kurtz Jefferson Y Chan

Nuclear factor E2-related factor 2 (Nrf2) is a cap-n-collar basic leucine zipper (CNC-bZIP) transcription factor that is well established as a master regulator of phase II detoxification and antioxidant gene expression and is strongly expressed in tissues involved in xenobiotic metabolism including liver and kidney. Nrf2 is also abundantly expressed in adipose tissue; however, the exact functio...

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