نتایج جستجو برای: پروتئین bdnf

تعداد نتایج: 26807  

2015
Fan-Chi Yeh Chung-Feng Kao Po-Hsiu Kuo Chunyu Liu

OBJECTIVES Brain-derived neurotrophic factor (BDNF) plays important roles in neuronal survival and differentiation; however, the effects of BDNF on mood disorders remain unclear. We investigated BDNF from the perspective of various aspects of systems biology, including its molecular evolution, genomic studies, protein functions, and pathway analysis. METHODS We conducted analyses examining se...

Journal: :Brain research 2011
Isabel Sánchez-Muñoz Franco Sánchez-Franco Mario Vallejo Antonio Fernández Nuria Palacios Miriam Fernández María Sánchez-Grande Lucinda Cacicedo

Brain derived neurotrophic factor (BDNF) increases the levels of somatostatin (SS) and its mRNA. To test the hypothesis that the regulation of SS synthesis by BDNF occurs at the transcriptional level and requires specific promoter sequences, cerebrocortical and PC12trkB neurons were transiently transfected with different constructs of the SS promoter fused to the luciferase and CAT reporter gen...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1996
S Marty P Carroll A Cellerino E Castrén V Staiger H Thoenen D Lindholm

Brain-derived neurotrophic factor (BDNF) is widely expressed in the central nervous system, where its function is poorly understood. The aim of this study was to investigate the effects of BDNF on the differentiation of hippocampal nonpyramidal neurons using organotypic slice cultures prepared from postnatal rats. The application of BDNF induced an increase in immunostaining for the microtubule...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Yu-Hui Wong Chia-Ming Lee Wenjun Xie Bianxiao Cui Mu-ming Poo

Brain-derived neurotrophic factor (BDNF) is known to modulate synapse development and plasticity, but the source of synaptic BDNF and molecular mechanisms regulating BDNF release remain unclear. Using exogenous BDNF tagged with quantum dots (BDNF-QDs), we found that endocytosed BDNF-QDs were preferentially localized to postsynaptic sites in the dendrite of cultured hippocampal neurons. Repetiti...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2007
ChuanFeng Wang Eric Bomberg Charles Billington Allen Levine Catherine M Kotz

Brain-derived neurotrophic factor (BDNF) decreases food intake and body weight, but few central sites of action have been identified. The hypothalamic paraventricular nucleus (PVN) is important in energy metabolism regulation, and expresses both BDNF and its receptor. We tested three hypotheses: 1) PVN BDNF reduces feeding and increases energy expenditure (EE), 2) PVN BDNF-enhanced thermogenesi...

Journal: :The Journal of biological chemistry 2010
Linda Lin-yan Wu Yongjun Fan Shihua Li Xiao-Jiang Li Xin-Fu Zhou

Brain-derived neurotrophic factor (BDNF) plays a pivotal role in brain development and synaptic plasticity. It is synthesized as a precursor (pro-BDNF), sorted into the secretory pathway, transported along dendrites and axons, and released in an activity-dependent manner. Mutant Huntingtin with expanded polyglutamine (polyQ) and the V66M polymorphism of BDNF reduce the dendritic distribution an...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Subhash C Pandey Huaibo Zhang Adip Roy Kaushik Misra

Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family of neurotrophins and plays a vital role in synaptic plasticity. This study investigated the involvement of the amygdaloid BDNF system in molecular mechanisms underlying anxiety and alcohol-drinking behaviors. Male Sprague Dawley rats were cannulated targeting central amygdala (CeA), medial amygdala (MeA), or ...

Journal: :Obesities 2022

Adverse childhood experiences (ACEs) may predict markers of neurocognitive performance (i.e., executive function; EF) and brain health/plasticity brain-derived neurotrophic factor; BDNF). This pilot examined: (1) ACES history current EF performance, (2) ACEs BDNF levels, (3) levels. We hypothesized that higher would be associated with lower scores these patterns serum Given the nature study, em...

Journal: :European Psychiatry 2023

Introduction Psychotherapy is a treatment of proven efficacy in bipolar disorder (BD), but little known about the molecular and cellular mechanisms that it produces brain. Brain-derived neurotrophic factor (BDNF) thought to be important neuroplasticity could increased by psychopharmaceuticals psychotherapy BD patients, evidence literature limited. Objectives To analyze scientific studies relate...

Journal: :Physiological genomics 2016
José R Lemos Cleber R Alves Sílvia B C de Souza Julia D C Marsiglia Michelle S M Silva Alexandre C Pereira Antônio L Teixeira Erica L M Vieira José E Krieger Carlos E Negrão Guilherme B Alves Edilamar M de Oliveira Wladimir Bolani Rodrigo G Dias Ivani C Trombetta

Besides neuronal plasticity, the neurotrophin brain-derived neurotrophic factor (BDNF) is also important in vascular function. The BDNF has been associated with angiogenesis through its specific receptor tropomyosin-related kinase B (TrkB). Additionally, Val66Met polymorphism decreases activity-induced BDNF. Since BDNF and TrkB are expressed in vascular endothelial cells and aerobic exercise tr...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید