نتایج جستجو برای: پروتئینα 1a
تعداد نتایج: 31310 فیلتر نتایج به سال:
Adult b-cell dysfunction, a hallmark of type 2 diabetes, can be programmed by adverse fetal environment. We have shown that fetal glucocorticoids (GCs) participate in this programming through inhibition of b-cell development. Here we have investigated the molecular mechanisms underlying this regulation. We showed that GCs stimulate the expression of peroxisome proliferator–activated receptor-g ...
We constructed an expression vector for a fusion protein [ANG II type 1a receptor-green fluorescent protein (AT(1a)R-GFP)] consisting of enhanced GFP attached to the COOH terminus of the rat AT(1a)R. Chinese hamster ovary (CHO) cells transfected with AT(1a)R-GFP demonstrated specific, high-affinity (125)I-labeled ANG II binding (IC(50) 21 nM). ANG II exposure stimulated sodium-proton exchange a...
Serotonin receptors 5-HT(1A) and 5-HT(7) are highly coexpressed in brain regions implicated in depression. However, their functional interaction has not been established. In the present study we show that 5-HT(1A) and 5-HT(7) receptors form heterodimers both in vitro and in vivo. Foerster resonance energy transfer-based assays revealed that, in addition to heterodimers, homodimers composed eith...
The present study demonstrated that 5-HT receptor mRNA was expressed with moderate level in the NRM neurons. Most of 5-HT 1A 1A receptor mRNA positive cells were 5-HT neurons, suggesting the majority of 5-HT receptor in the NRM might be autoreceptors. Eight 1A hours after carrageenan inflammation, the expression of 5-HT receptor mRNA in the NRM neurons, especially in the 5-HT neurons, 1A was si...
Carnitine palmitoyltransferase-1 (CPT-1) liver isoform, or CPT-1a, is implicated in CNS control of food intake. However, the exact brain nucleus site(s) in mediating this action of CPT-1a has not been identified. In this report, we assess the role of CPT-1a in hypothalamic ventromedial nucleus (VMN). We stereotaxically injected an adenoviral vector containing CPT-1a coding sequence into the VMN...
SNARE proteins, syntaxin-1A (Syn-1A) and SNAP-25, inhibit delayed rectifier K(+) channels, K(v)1.1 and K(v)2.1, in secretory cells. We showed previously that the mutant open conformation of Syn-1A (Syn-1A L165A/E166A) inhibits K(v)2.1 channels more optimally than wild-type Syn-1A. In this report we examined whether Syn-1A in its wild-type and open conformations would exhibit similar differentia...
The transcription factor sterol regulatory element binding protein (SREBP)-1a plays a pivotal role in lipid metabolism. Using the SREBP-1a expressing human hepatoma cell line HepG2 we have shown previously that human SREBP-1a is phosphorylated at serine 117 by ERK-mitogen-activated protein kinases (MAPK). Using a combination of cell biology and protein chemistry approach we show that SREBP-1a i...
The rise in blood pressure during an acute aversive stress has been suggested to involve activation of angiotensin type 1A receptors (AT(1A)Rs) at various sites within the brain, including the rostral ventrolateral medulla. In this study we examine the involvement of AT(1A)Rs associated with a subclass of sympathetic premotor neurons of the rostral ventrolateral medulla, the C1 neurons. The dis...
واکنش تراکمی دو جزیی آلدیید، مالونونیتریل و دی مدون یکی از مهمترین روش کارهای استفاده شده موجود برای سنتز ترکیب های 2-آمینو-7،7- دی متیل -5 -اکسو-4-آریل-5،6،7،8- تترا هیدرو-4h-کرومن-3-کربونیتریل ها (5a-g)است. در تحقیق بهترین شرایط تجربی واکنش بنزآلدیید (1a-g)، مالونونیتریل (2)و دی مدون (4) در حضور zrocl2.8h2o در اتانول بصورت دو مدل واکنش نوناژلی در نظر گرفته شد، به این صورت که ابتدا واکنش بنز...
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