Methylene blue, currently in phase 3 clinical trials against Alzheimer Disease, disaggregates the Tau protein of neurofibrillary tangles by oxidizing specific cysteine residues. Here, we investigated if methylene blue can inhibit caspases via the oxidation of their active site cysteine. Methylene blue, and derivatives, azure A and azure B competitively inhibited recombinant Caspase-6 (Casp6), a...

Spectrophotometric measurements show that the non-medullated nerve of a lobster claw is capable of absorbing methylene blue, azure B, or acid fuchsin dissolved in sea water but this does not necessarily imply that the dyes penetrate into the interior of the nerve.

Most of us think we know some basic facts about how time works. The facts we believe we know are based on a few intuitions about time, which are, in turn, based on our conscious waking experiences. As far as I can tell, these intuitions about time are something like this: 1) There is a physical world in which events occur, 2) These events are mirrored by our perceptual recreation of them in ess...

Network connectivity policies are crucial for assuring the security and availability of large-scale datacenter. Managing these policies is fraught with complexity and operator errors. The difficulties are exacerbated when deploying large scale offerings of public cloud services where multiple tenants are hosted within customized isolation boundaries. In these large-scale settings it is impracti...

The advent of Cloud computing has given to researchers the ability to access resources that satisfy their growing needs, which could not be satisfied by traditional computing resources such as PCs and locally managed clusters. On the other side, such ability, has opened new challenges for the execution of their computational work and the managing of massive amounts of data into resources provid...

The rate of diffusion through the non-aqueous layer of the protoplasm depends largely on the partition coefficients mentioned above. Since these cannot be determined we have employed an artificial system in which chloroform is used in place of the non-aqueous layer of the protoplasm. The partition coefficients may be roughly determined by shaking up the aqueous solutions with chloroform and ana...

In this paper, they try to represent the importance of communication and interaction between an organization and its clients. Cloud CRM (Customer Relationship Model) is a dynamic application that is developed with latest technologies in order to mark a remarking presence of CRM process. This is built as a web application for both the customer and clients. Cloud CRM has exceptional features like...