Abstract Deoxynivalenol (DON) is a primary mycotoxin in cereal feed ingredients that negatively affects intake and immune function of pigs. Formation DON sulfonate (DONS) with sulfites has become an effective approach to mitigate the toxicities practice, but metabolic fate under sulfonation-based decontamination was not well defined. In this study, 48 nursery pigs (35 d age, 10.8 ± 1.3 kg) were...

The cosmopolitan genus Carex L. represented about 1,800-2,000 species mainly in temperate and cold regions of the world. 49 species of Carex found in North-eastern India and 33 species in the rest part of India. Systematics of different taxa (subgenera, sections species pairs etc.) of the genus is quite complicated. In Carex, utricle morphology and fruit epidermal silicabodies have been used to...

Glycosylation is an important plant defense mechanism and conjugates of Fusarium mycotoxins often co-occur with their parent compounds in cereal-based food and feed. In case of deoxynivalenol (DON), deoxynivalenol-3-O-β-D-glucoside (D3G) is the most important masked mycotoxin. The toxicological significance of D3G is not yet fully understood so that it is crucial to obtain this compound in pure...

In continuation of earlier works1) an unknown compound, C20H340, m・P・ 182~183。, [α]15D +14.52°,obtained from the neutral portion of wooe resin of Cryptmeria japonica D. Don, has been examined. In part VIII1) of this series, an isolation of this compound has been described in detail. This compound, called phyllocladanol, is not apparent to have been previously isolated. Phyllocladanol is colorle...

The trichothecene deoxynivalenol (DON) binds to eukaryotic ribosomes and triggers p38-driven proinflammatory gene expression in the macrophage-a response that is dependent on both double-stranded RNA-activated protein kinase (PKR) and hematopoietic cell kinase (Hck). Here we elucidated critical linkages that exist among the ribosome and these kinases during the course of DON-induced ribotoxic s...

It has been shown that DON has negative effects on the active transport of some nutrients in the small intestine of chickens. The plausible interactions between food contaminants and natural components could be high. The present study investigated the effects of DON on the presence or absence of dietary inulin on the electrophysiological response of the gut to glucose. Ussing chamber studies we...