OBJECTIVE To describe the characteristics and risk of bacille Calmette-Guérin (BCG) vaccine related disease in human immunodeficiency virus (HIV) infected infants. METHODS Systematic literature review of articles published from 1950 to April 2009 in the English language. We identified all microbiologically confirmed cases of disseminated BCG disease in vertically HIV-infected children reporte...

Tuberculosis (TB), caused by the intracellular bacterium Mycobacterium tuberculosis (Mtb), remains a major health threat. A live, attenuated mycobacterium known as Bacille Calmette-Guérin (BCG), derived from the causative agent of cattle TB, Mycobacterium bovis, has been in clinical use as a vaccine for 90 years. The current incidence of TB demonstrates that BCG fails to protect sufficiently ag...

Neutrophils are often seen first at sites of granulomatous inflammation but their contribution to monocyte recruitment and granuloma formation is unknown. We tested the hypothesis that neutrophils release chemotaxins which attract monocytes. We found that rapid accumulations of fluid and influxes of neutrophils followed by monocytes occurred in bacillus Calmette--Guérin (BCG)-sensitized rabbits...

BACKGROUND Recent studies have suggested that Bacille Calmette-Guerin (BCG) vaccination may have a non-specific beneficial effect on infant survival and that a BCG scar may be associated with lower child mortality. No study has previously examined the influence of BCG vaccination on cause of death. METHODS Two cohorts (A and B) were used to describe the mortality pattern for children with and...

We take advantage of a state-of-art semi analytic model galaxy formation, and the presented in \citet{contini21a}, to investigate mass distribution Brightest Cluster Galaxies (BCGs) Intra-Cluster Light (ICL) by addressing two points: (1) region transition between BCG dominated an ICL one, and; (2) relation total BCG+ICL one alone. find radius be independent both halo masses, with average 60$\pm...

We have previously shown that bacillus Calmette-Guérin (BCG) inactivated by extended freeze-drying (EFD) reduces airway hyperresponsiveness, whereas live and heat-killed BCG fail to do so. However, the cells involved in the protective effect and the signaling and transcriptional networks that could reprogram T cell commitment after EFD BCG treatment remained to be elucidated. We investigated wh...

Intravesical instillation of Mycobacterium bovis bacillus Calmette-Guérin (BCG) has been used for treating bladder cancer for 3 decades. However, BCG therapy is ineffective in approximately 30-40% of cases. Since evidence supports the T helper type 1 (Th1) response to be essential in BCG-induced tumor destruction, studies have focused on enhancing BCG induction of Th1 immune responses. Although...

Healthy volunteers were randomized to receive percutaneous or intradermal bacille Calmette-Guérin (BCG) vaccination. Delayed-type hypersensitivity (DTH) to tuberculin, as well as proliferative and interferon-gamma responses in peripheral blood mononuclear cells stimulated by whole cell lysates and culture filtrates of Mycobacterium tuberculosis and Mycobacterium avium-intracellulare, were compa...

the calmette-güerin vaccine (bcg) is administered to all the newborns in iran in order to prevent tuberculosis. complications of this vaccine are uncommon. we report disseminated bcg disease in 17 patients less than 10 years old. this is a retrospective study of total of 17 cases who were admitted in children medical center hospital with systemic syndrome compatible with mycobacterium disease w...

in this study, 16 eligible dogs were randomly divided in to 4 groups. group 1, 2, 3 and 4 received autoclaved leishmania infantum with bcg (ali+bcg), autoclaved leishmania major + bcg (alm + bcg), bcg alone and normal saline, respectively. dogs received the vaccines intradermally 3 times at 30 days intervals. all dogs were followed up 2 months intervals by leishmanin skin test and anti -leishma...