In this paper we present the agent architecture development environment ADE, intended for the design, implementation, and testing of distributed agent architectures. After a short review of architecture development tools, we discuss ADE’s unique features that place it in the intersection of multiagent systems and development kits for single agent architectures. A detailed discussion of the gene...

OBJECTIVE Rates of AIDS defining event (ADE), serious ADE and death by CD4 and HIV RNA categories before and after combination antiretroviral therapy (cART) initiation are lacking for high CD4 counts. METHODS Event rates were estimated within CD4 cell strata using a Poisson regression model adjusting for sex, exposure category, age, and current HIV RNA (<4, 4-4.99, > or =5 log copies/ml), and...

Interferon-inducible transmembrane (IFITM) proteins restrict the entry processes of several pathogenic viruses, including the flaviviruses West Nile virus and dengue virus (DENV). DENV infects cells directly or via antibody-dependent enhancement (ADE) in Fc-receptor-bearing cells, a process thought to contribute to severe disease in a secondary infection. Here we investigated whether ADE-mediat...

Today, test engineers will spend most of their development time working with an ADE. Hence, it is critical to select an ADE that is not only intuitive, but can support multiple platforms and integrate easily with measurement and control services such as drivers. Other features that should be considered when selecting an ADE for the development of your test system are its presentation and report...

Adverse Drug Events (ADE) due to medication errors and human factors are a major public health issue. They endanger patient safety and cause considerable extra healthcare costs. The European project PSIP (Patient Safety through Intelligent Procedures in medication) aims to identify and prevent ADE. Data mining of the structured hospital data bases will give a list of observed ADE with frequenci...

Antibody-dependent enhancement (ADE) is an important safety concern for vaccine development against dengue virus (DENV) and its antigenically related Zika (ZIKV) because may prime deleterious antibodies to enhance natural infections. Cross-reactive targeting the conserved fusion loop epitope (FLE) are known as main sources of ADE. We design ZIKV immunogens engineered change FLE conformation but...

Adverse drug events (ADEs) may cause serious injuries including death. Spontaneous reporting of ADEs plays a great role in detection and prevention of them, however, underreporting always exists. Although several interventions have been utilized to solve this problem, they are mainly based on experience and the rationale for choosing them has no theoretical base. The vast variety of behavioral ...