نتایج جستجو برای: نقص در عملکرد آنزیم g6pd
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در این مقاله، بهمنظور رفع برخی محدودیتهای شناسایی ساختمان تصاویر چندطیفی، از دادة SAR بهمنزلة مکمل استفاده میشود. روش پیشنهادی، برای استفادة همزمان اطلاعات مفید رادار و استراتژی مبتنیبر تلفیق تصاویر، با هدف ساختمان، مطرح همچنین، ازآنجاکه انتخاب ویژگی نقش بسزایی طبقهبندی عوارض دارد، اغلب روشهای مرسوم رایج زمینه، مانند الگوریتم ژنتیک، نیازمند دادههای آموزشیاند؛ اما دردسترسنبودن همیشگی...
BACKGROUND Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is one of the most common human genetic abnormalities, with a high prevalence in Sardinia, Italy. Evidence indicates that G6PD-deficient patients are protected against vascular disease. Little is known about the relationship between G6PD deficiency and diabetes mellitus. The purpose of this study was to compare G6PD deficiency preva...
OBJECTIVE Glucose 6-phosphate dehydrogenase (G6PD) maintains cellular NADPH levels, which are essential for cellular functions, such as vascular endothelial growth factor (VEGF)-induced angiogenesis. The molecular mechanisms regulating G6PD in angiogenesis are not fully understood. Because tyrosine phosphorylation is a key regulatory pathway for VEGF-mediated endothelial cell (EC) responses, we...
BACKGROUND Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect and affects more than 400 million people worldwide. This deficiency is believed to protect against malaria because its global distribution is similar. However, this genetic disorder may be associated with potential hemolytic anemia after treatment with anti-malarials, primaquine or other 8-amin...
Polyunsaturated fatty acids inhibit the expression of hepatic glucose-6-phosphate dehydrogenase (G6PD) by changes in the amount of G6PD pre-mRNA in the nucleus in the absence of changes in the transcription rate of the gene. We have compared the nuclear accumulation of partially and fully spliced mRNA for G6PD in the livers of mice fed diets high versus low in polyunsaturated fat. Consumption o...
Alphab-crystallin, a small heat-shock protein has been shown to prevent the aggregation of other proteins under various stress conditions. We have investigated the role of alphaB-crystallin in the reactivation of denaturant [GdmCl (guanidinium chloride)]-inactivated G6PD (glucose-6-phosphate dehydrogenase). Studies indicate that unfolding and inactivation of G6PD by GdmCl proceeds via formation...
هیپرپلازی مادرزادی آدرنال یک عارضه اتوزومال مغلوب است که به علت نقص در یکی از آنزیم هایی که در مسیر ساخته شدن کورتیزول از کلسترول دخالت دارند، بوجود میآید. در 90% بیماران مبتلا به این بیماری نقص آنزیم 21 هیدروکسیلاز (210HD) وجود دارد.اختلال در ساخته شدن کورتیزول موجب افزایش ترشح هورمون آدرنوکورتیکوتروپین (ACTH) و در نتیجه هیپرپلازی غدد فوق کلیه و افزایش تولید برخی از استروییدها میشود که بر ح...
Plasmodium falciparum growth is impaired in glucose-6-phosphate dehydrogenase (G6PD)-deficient red blood cells (RBCs), and malaria has been implicated in the spreading of deficient variants in malaria-endemic areas. Recent reports suggest that the malaria parasite can adapt itself to grow in these variant RBCs by producing its own G6PD, but studies on parasite G6PD are very limited. In this rep...
I NVESTJGATIONS OF RED CELL GLUCOSE-6-PHOSPHATE DEHYDROGENASE ( D-glucose-6-phosphate: NADP oxidoreductase, EC 1.1.1.49; G6PD ) in different human populations have shown that more than 50 variants exist at this time.1’2 Genetic studies are compatible with X-linkage of all G6PD variants. Some variants are associated with normal enzyme activity and therefore are not accompanied by any clinical ma...
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