PURPOSE This randomised trial was designed to investigate the activity and toxicity of continuous infusion etoposide phosphate (EP), targeting a plasma etoposide concentration of either 3 micrograms/ml for five days (5d) or 1 microgram/ml for 15 days (15d), in previously untreated SCLC patients with extensive disease. PATIENTS AND METHODS EP was used as a single agent. Plasma etoposide concen...

The accurate measurement of biologically active erythropoietin (Ep) in human serum and plasma using present in vivo and in vitro bioassays is difficult because of the presence of both inhibitors and non-Ep stimulators of erythropoiesis. We have developed a simple procedure to quantitatively purify Ep from serum and plasma for subsequent testing in the phenylhydrazine-treated mouse spleen cell a...

OBJECTIVE We aimed to evaluate the alterations in serum levels of platelet indices such as mean platelet volume (MPV) and platelet distribution width (PDW) in ectopic pregnancy (EP) and discuss the mechanism of the alterations in MPV and PDW. METHODS This retrospective evaluation of 153 tubal EP patients (39 ruptured and 114 non-ruptured) admitted to our clinic between 2009 and 2013 and 67 he...

The problem of the resistive wall mode (RWM) is studied in cylindrical geometry and compared to experimental observations from HBT-EP tokamak. In HBT-EP, a dynamical RWM plasma response is studied by applying static, rotating and phase-flip external magnetic perturbations. The plasma response to the applied perturbation is included via the permeability matrix, P = 1/(−s+iα). Here, s is the norm...

The articles featured in the Blood Flashback series were selected and the commentaries written by the Blood Editors. Complete versions of all the articles in the series, commemorating the journal’s 70th-anniversary year, can be found on the Blood Web site at www.bloodjournal.org/collection/blood-flashback. Leading the Way in Hematology For personal use only. on August 31, 2016. by guest www.bl...

We have measured the fully inclusive K+ → μ+ν(γ) absolute branching ratio with the KLOE experiment at DAΦNE, the Frascati φ–factory. From some 865,283 K+ → μ+ν(γ) decays obtained from a sample of ∼5.2 × 108 φ-meson decays, we find BR(K+ → μνμ(γ))=0.6366±0.0009stat.±0.0015syst., corresponding to an overall fractional error of 0.27%. Using recent lattice results on the decay constants of pseudosc...

The title compound, C6H12O6, a C-3 position epimer of glucose, was crystallized from an equimolar mixture of d- and l-allose. It was confirmed that d-allose (l-allose) formed β-pyran-ose with a (4) C 1 ((1) C 4) conformation in the crystal. In the crystal, molecules are linked by O-H⋯O hydrogen bond, forming a three-dimensional framework. The cell volume of the racemic β-d,l-allose is 739.36 (3...

Introduction: Cardiac arrhythmias, e.g. atrial fibrillation and ventricular tachycardia, are increasingly treated by electrophysiological (EP) interventions [1]. Applying MR for guiding these interventions offers advantages like 3D visualization of the cardiac soft tissue in relation to the catheter, visualization of the treatment effect and absence of ionizing radiation [2,3]. The step towards...

Ependymin, a prominent protein of the brain's extracellular fluid (ECF) was previously implicated in the consolidation of memory and in the activity-driven sharpening of the retinotectal projection. Because both these phenomena probably involve the growth and elaboration of appropriate synapses, we have tested whether ependymin can serve as a substrate for the growth of axons from goldfish reti...