OBJECTIVE To investigate potential drugs for diabetic nephropathy (DN) using whole-genome expression profiles and the Connectivity Map (CMAP). METHODOLOGY Eighteen Chinese Han DN patients and six normal controls were included in this study. Whole-genome expression profiles of microdissected glomeruli were measured using the Affymetrix human U133 plus 2.0 chip. Differentially expressed genes (...

To identify determinants of peripheral involvement in spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) the influence of CAG repeat length, age of onset, disease duration and age on the results of nerve conduction studies was analysed in 58 patients with SCA3/MJD. Patients with SCA3/MJD showed marked reduction of compound muscle action potential (CMAP) and sensory nerve action pot...

OBJECTIVES To determine if transcutaneous electrical stimulation of the cervical roots can be used to diagnose proximal conduction block (CB) in multifocal motor neuropathy (MMN) and whether it can reliably distinguish MMN from amyotrophic lateral sclerosis (ALS). METHODS Compound muscle action potentials (CMAPs) over the abductor digiti minimi (ADM) were evoked by supramaximal stimulation of...

Objective: Carpal tunnel syndrome (CTS) is the most common peripheral neuropathy affecting upper limbs. Various treatment methods exist for this disease, but only a few reports have compared effects of various treatments using objective indicators. This study analyzed changes in electrophysiological parameters after carpal release.Methods: In patients planning to undergo surgical CTS, studies, ...

The effect of chest wall configuration on the diaphragm electromyogram (EMGdi) was evaluated in five healthy subjects with an esophageal electrode for both interference pattern EMGdi (voluntary contractions) and electrically evoked diaphragm compound muscle action potentials (CMAPs). Diaphragm CMAPs (both unilateral and bilateral) were evaluated for the baseline-to-peak amplitude (Ampl), the ti...

BACKGROUND Minimally invasive surgery has been developed with various innovative surgical tools. Ultrasonic (US) blades have been introduced as an alternative to conventional electrocautery (EC) monopolar device. The purpose of the present study was to evaluate the effects of surgical devices used for muscle dissection close to peripheral nerves on motor nerve function using electromyographic (...

ObjectiveSince motor nerve conduction slowing can occur due to loss of large axons, we investigate the profile in ALS and identify limits beyond which diagnosis exclusive axonal is unlikely.MethodsFirst, using linear regression analysis, established range 76 CIDP patients. Demyelinating confidence intervals were defined by assessing velocity (CV), distal latency (DML), F-wave (F) relation compo...

Gridded fields (analyses) of global monthly precipitation have been constructed on a 2.5° latitude–longitude grid for the 17-yr period from 1979 to 1995 by merging several kinds of information sources with different characteristics, including gauge observations, estimates inferred from a variety of satellite observations, and the NCEP–NCAR reanalysis. This new dataset, which the authors have na...

OBJECTIVE To compare electrical impedance myography (EIM) 50 kHz phase to weight, motor score, paw grip endurance (PGE), CMAP amplitude, and MUNE for the identification of disease progression and the effect of riluzole in the SOD1 G93A mouse. METHODS Twenty-three animals received 8 mg/kg/day riluzole in the drinking water starting at 6 weeks of age; 22 animals served as controls. Weight, moto...