The pathway for copper (Cu) uptake across the mucosal membrane into intestinal cells has not been elucidated in fish. Copper accumulation in freshly isolated intestinal cells from rainbow trout Oncorhynchus mykiss was measured after exposure to 0-800 micromol l(-1) CuSO(4) for 15 min. With external Cu concentration (Cu(o)) of 800 micromol l(-1), the rate of Cu accumulation by cells was 1.88+/-0...

The acidity and stability constants of M(Trp) M: Cu, Cu(Bpy)2+, and Cu(Phen)2+ complexes, were determined by potentiometric pH titration. It is shown that the stability of the binary Cu(Trp) complex is determined by the basicity of the carboxylate group on one side and amino group on the other side. It is demonstrated that the equilibrium, Cu(Har)2+ + Cu(Trp) Cu(Har)(Trp) + Cu, is displacement ...

UNLABELLED The purpose of this study is to reveal characteristics of (64)Cu-labeled diacetyl-bis(N(4)-methylthiosemicarbazone) ([(64)Cu]Cu-ATSM) during cell proliferation and hypoxia by autoradiography imaging and immunohistochemical staining. METHODS The intratumoral distributions of [(64)Cu]Cu-ATSM and [(18)F]-2-fluoro-2-deoxy-D-glucose ([(18)F]FDG) in mice implanted with Lewis lung carcino...

An Mn for Cu substitution on cellular prion proteins (PrP(c)) in the brain that results in biochemical changes to PrP(c) has been implicated in the pathogenesis of transmissible spongiform encephalopathies. Recent research in the mature bovine does not support this theory. The present study tested this hypothesis by using progeny from gestating cows receiving Cu-deficient diets or Cu-deficient ...

There is a lack of agreement on index of Cu status and reliable and sensitive biomarkers are still required. The purpose of this present work was to assess in rats the sensitivity of diamine oxidase (DAO) activity, a recently proposed biomarker, to modifications in dietary Cu intake in comparison with other plasma biomarkers of Cu status. We also evaluated the effect of Cu dietary level on Cu a...

A 493-d study was conducted to determine the impact of a severe, long-term Cu deficiency on Fe metabolism in beef cattle. Twenty-one Angus calves were born to cows receiving one of the following treatments: 1) adequate Cu (+Cu), 2) Cu deficient (-Cu), and 3) Cu deficient plus high Mn (-Cu+Mn). Copper deficiency was induced through the addition of 2 mg of Mo/kg of DM. After weaning, calves remai...

This communication reports the discovery of several small-pore Cu-zeolites and zeotypes that produce methanol from methane and water vapor, and produce more methanol per copper atom than Cu-ZSM-5 and Cu-mordenite. The new materials include Cu-SSZ-13, Cu-SSZ-16, Cu-SSZ-39, and Cu-SAPO-34.

Like all other animal species, terrestrial pulmonate snails require Cu as an essential trace element. On the other hand, elevated amounts of Cu can exert toxic effects on snails. The homeostatic regulation of Cu must therefore be a pivotal goal of terrestrial pulmonates to survive. Upon administration of Cu, snails accumulate the metal nearly equally in most of their organs. Quantitative studie...