To examine the neurophysiological and cognitive characteristics of thought disturbance in schizophrenic patients, we examined the amplitude, latency, and topography of a specific event-related brain potential (ERP), the N400, which is elicited by semantically incongruent words and phrases. Twelve chronic schizophrenic patients and twelve age-matched control subjects read sentences presented vis...

We present event-related brain potential evidence from language comprehension that the N400-modulation during noun-phrase integration is a function of the type of referential dependency that is established (identity versus inference) and the saliency (in the following understood as the sum of factors that influence the degree of accessibility of an entity in the mental model) of the information...

In a typical visual Event Related Potential (ERP) study, the stimulus is presented centrally on the screen. Normally an ERP response will be measured provided that the participant directs their gaze towards the stimulus. The aim of this study was to assess how the N400 component of an ERP was affected when the stimulus was presented in the foveal, parafoveal or peripheral vision of the particip...

We used ERPs to investigate the pre-activation of form and meaning in language comprehension. Participants read high-cloze sentence contexts (e.g., ‘‘The student is going to the library to borrow a. . .”), followed by a word that was predictable (book), form-related (hook) or semantically related (page) to the predictable word, or unrelated (sofa). At a 500 ms SOA (Experiment 1), semantically r...

The brain is able to acquire information about an unknown word's meaning from a highly constraining sentence context with minimal exposure. In this study, we investigate the potential contributions of the cerebral hemispheres to this ability. Undergraduates first read weakly or strongly constraining sentences completed by known or unknown (novel) words. Subsequently, their knowledge of the prev...

The processing of literal, novel metaphorical and semantically anomalous expressions in native Dutch speakers and German Dutch learners was examined using event-related potentials. The N400 component was determined for expressions which were formulated in an “A is a B” form and varied in their degree of figurativeness. A three-choice task was used in which the participants had to decide whether...

BACKGROUND Disturbances in language associations were among the first clinical symptoms reported for individuals described as schizophrenic (Bleuler 1911/1950). Currently, associative language disturbance is a diagnostic feature of schizophrenia (American Psychiatric Association 1994); however, the mechanisms that produce this symptom remain unknown. In the present study, two candidate psycholo...

The effects of working memory (WM) on the semantic N400 response were studied using high-resolution event-related brain potentials (ERPs). Participants were presented with semantically related sentence pairs and the terminal word congruence was varied in the second sentence. WM load was varied for the sentence pairs using a modified fan procedure [J.R. Anderson, Retrieval of propositional infor...

The N400 ERP is an electrophysiological index of semantic processing. Its amplitude varies with the semantic category of words, their concreteness, or whether their meaning matches that of a preceding context. The results of a number of studies suggest that these effects could be markedly reduced or suppressed for stimuli that are repeated. Nevertheless, we have recently shown that significant ...