Within neurons, Ca2+-dependent inactivation (CDI) of voltage-gated L-type Ca2+ channels shapes cytoplasmic Ca2+ signals. CDI is initiated by Ca2+ binding to channel-associated calmodulin and subsequent Ca2+/calmodulin activation of the Ca2+-dependent phosphatase, calcineurin (CaN), which is targeted to L channels by the A-kinase-anchoring protein AKAP79/150. Here, we report that CDI of neuronal...

Clostridium difficile infection (CDI) is now the leading cause of nosocomial infection. There has been an upsurge of CDI in patients with inflammatory bowel disease (IBD). IBD patients with CDI have increased morbidity and mortality. The establishment, proliferation, and recurrence of CDI in IBD patients form a complex interplay of microbial, environmental, and host-susceptibility factors. Diff...

BACKGROUND Clostridium difficile infection (CDI) is the most common healthcare associated infection and is highly prevalent in Europe and North America. Limited data is available on the prevalence of CDI in Asia. However, secular increases in prevalence of risk factors for CDI suggest that it may be emerging as a major cause of morbidity, highlighting the urgent need for a systematic study of t...

INTRODUCTION Clostridium difficile is a common cause of nosocomial diarrhea, especially in elderly patients. This study aimed to analyze the clinical features and assess the risk factors associated with Clostridium difficile infection (CDI) in elderly hospitalized patients. METHODOLOGY A retrospective case-control study was conducted among elderly hospitalized patients (> 60 years of age) in ...

OBJECTIVE To determine the attributable inpatient costs of recurrent Clostridium difficile infections (CDIs). DESIGN Retrospective cohort study. SETTING Academic, urban, tertiary care hospital. PATIENTS A total of 3,958 patients aged 18 years or more who developed an initial CDI episode from 2003 through 2009. METHODS Data were collected electronically from hospital administrative datab...

Clostridium difficile infection (CDI) is the most common cause of hospitalacquired infectious diarrhea in the United States. Although C. difficile is widelyrecognized as a pathogen among hospitalized populations, CDI has emerged in the community setting and may be under-diagnosed. This study sought to increase knowledge about the incidence of, risk factors for, and outcomes associated with comm...

Nucleic acid amplification testing (NAAT) is increasingly being adopted for diagnosis of Clostridium difficile infection (CDI). Data from 3 states conducting population-based CDI surveillance showed increases ranging from 43% to 67% in CDI incidence attributable to changing from toxin enzyme immunoassays to NAAT. CDI surveillance requires adjustment for testing methods.

blockers did not seem to be a risk factor for CDI in patients who underwent allogeneic SCT. Diarrhea was a very common complication of hematologic malignancy in patients who underwent SCT. In fact, only 3 patients did not develop diarrhea during their hospitalization. Almost one-third of the patients who underwent allogeneic SCT also received a diagnosis of CDI. Previous studies have reported i...