Transforming growth factor beta (TGF-beta) signaling via Smad proteins occurs in various cell types. However, whereas the biological response to TGF-beta can be as distinct as growth promoting (i.e., mesenchymal cells) versus growth inhibiting (i.e., epithelial cells), few discernible differences in TGF-beta signaling have been reported. In the current study, we examined the role of Ras in the ...

تعمج تانايبلا . ةيجهنم ةعجارم تناك ةساردلا هذه :هقیرطلا و ةصالخا تاملكلا لامعتساو تانايبلا ةدعاق يف ثحبلا للاخ نم زجالحا " :یتلاا تناك ةصالخا تاملكلا .ثحبلا یف قمعتلا ريياعلما . " ةطبثلما لماوعلا " و "ءاسنلل ةدلاولا لبق ةياعرلا " لوصو" ٬" یف قمعتلا وةساردلا دعب .OR ،AND تناك ةيقطنلما لماوعلا تلااقم تددحو تضفر ةطبارتم ريغ تلااقم ، هفلتخلما تلااقلما تلااقلما رايتخلاا رايعم .تلااقلما لذل اصخلم اها...

Our previous data demonstrated that type II cGMP-dependent protein kinase (PKG II) inhibited epidermal growth factor (EGF)-induced MAPK/ERK/JNK-mediated signal transduction through inhibiting the phosphorylation/activation of the epidermal growth factor receptor (EGFR). Since the EGFR also binds with several other ligands as well as EGF, the present study was designed to investigate whether PKG...

We investigated the expression of ERK, p38 mitogen-activated protein kinase (p38), and JNK in renal tubules of diabetic rats following 3 wk after streptozotocin injection (DM). Although the expression of ERK was not different between controls and DM, phosphorylated ERK was expressed more intensely in DM. p38 And phosphorylated p38 were detected only in the diabetic kidney and were localized in ...

ةــصلاـخلا : سا وه ةنيجهلا ملعتلا ةمظنأ يدحت نإ تامولعملا رداصم دحأ نم ةعبانلا تامولعملا لامعت رخآ ردصم نع ةمجانلا صئاقنلا ةنزاومل . كلذ و ةدعاو ثحب ةهجو لثمي يزمرلا يكبشلا جزملا نإ ةيزمرلا نيتقيرطلا نيب دضاعتلا نلأ ) ةيرظنلا ( ةيكبشلا و ) ةيبيرجتلا ( لآ لامعتسا نم ةيلاعف رثآأ ادح ىلع امهنم ةدحاو . لا اذه فصي ،يزمر يكبش فنصم ةطساوب ةيفرحلا ةيبرعلا غلابملا ىلع فرعتلل اماظن ثحب ،ةيلاملا غلابملا...

ناآ دقل رهوج ،ةيفخ ةفصب تامولعملا لاسرإ و لاصتلاا عوضوم مدقلا ذنم مامتهلاا و ديعب نمز ذنم عساو لكشب مدختست ةيصنلا قئاثولا تناآ ، صوصنلا يف تامولعملا ءافخلإ ةفلتخم اًقرط مويلا ىتح نمز ذنم دهشن نحن كلذل ) Text Steganography .( لاقملا اذه نإ ط لوانتي ةيبرعلا و ةيسرافلا صوصنلا يف تامولعملا ءافخلإ ةديدج ةقير . و دوآ ينويلا ةفصاوم يف دجوي ) Unicode ( ءايلا فرحل نافلتخم نازمر » ى « ، فاكلا فرحل كلذآو...

BACKGROUND To evaluate the effect of bradykinin (BK) on TGF-β1-induced retinal pigment epithelial (RPE) cell proliferation and extracellular matrix secretion and to elucidate the relationship between BK and the Erk/Akt signaling pathway. METHODS The effects of BK on TGF-β1-induced RPE cell proliferation were examined via CCK-8 assay. Cell culture supernatant collagen I concentrations were mea...

Epithelial-mesenchymal transitions (EMTs) are an essential manifestation of epithelial cell plasticity during morphogenesis, wound healing, and tumor progression. Transforming growth factor-beta (TGF-beta) modulates epithelial plasticity in these physiological contexts by inducing EMT. Here we report a transcriptome screen of genetic programs of TGF-beta-induced EMT in human keratinocytes and p...