Ozone is a common environmental air pollutant leading to respiratory illness. The mechanisms regulating ozone-induced airway inflammation remain poorly understood. We hypothesize that ozone-triggered inflammasome activation and interleukin (IL)-1 production regulate neutrophilic airway inflammation through IL-17A. Pulmonary neutrophilic inflammation was induced by extended (72 h) low-dose (0.7 ...

Highly porous carbons have been prepared by the chemical activation of two mesoporous carbons obtained by using hexagonal- (SBA-15) and cubic (KIT-6)-ordered mesostructured silica as hard templates. These materials were investigated as sorbents for CO(2) capture. The activation process was carried out with KOH at different temperatures in the 600-800°C range. Textural characterization of these ...

BACKGROUND Acute megakaryocytic leukemia (AMkL) in Down syndrome (DS) children is uniformly associated with somatic GATA1 mutations, which result in the synthesis of a shorter protein (GATA1s) with altered transactivation activity compared to the wild-type GATA1. It is not fully established whether leukemogenesis and therapeutic responses in DS AMkL patients are due to loss of the wild-type GAT...

The research presented in this dissertation is aimed at the development of electrocatalysts for the oxygen reduction reaction (ORR) based on ordered mesoporous carbons (OMCs). The ORR is a key reaction in electrochemical energy devices such as fuel cells and metal-air batteries. Because of its sluggish kinetics compared to its counterpart reaction (i.e., hydrogen oxidation reaction in fuel cell...

Potassium (K+) deprivation-induced apoptosis of cerebellar granule neurons requires new mRNA and protein synthesis. Using a fluorogenic substrate for interleukin-1beta converting enzyme (ICE), we show that K+ deprivation of cerebellar granule neurons induces cycloheximide-sensitive ICE-like protease activity. A peptide inhibitor of ICE-like protease activity, Ac-YVAD-chloromethylketone (Ac-YVAD...