PURPOSE Sorafenib is a multi-targeted tyrosine kinase inhibitor with therapeutic efficacy in several malignancies. Sorafenib may exert its anti-neoplastic effect in part by altering vascular permeability and reducing intra-tumoral interstitial hypertension. As correlative science with a phase II study in patients with advanced soft-tissue sarcomas (STS), we evaluated the impact of this agent on...

One of the fundamental results of descriptive complexity theory, due to Immerman [12] and Vardi [17], says that a class of ordered finite structures is definable in fixed-point logic if, and only if, it is computable in polynomial time. Much effort has been spent on the problem of capturing polynomial time, that is, describing all polynomial time computable classes of not necessarily ordered fi...

Background: High tumour interstitial fluid pressure (IFP) has been adversely linked to poor drug uptake in patients, and to treatment response following radiotherapy in cervix cancer patients. In this study we measuredcompared IFP values in an array of murine and xenograft models, spontaneously arising or transplanted either intramuscularly (i/m) or orthotopically and analysed their relationshi...

  The gastric inflammatory fibroid polyp (IFP) is a rare benign tumor of unknown etiology that is localized mainly in the antrum and presents endoscopically as submucosal mass. The lesion manifests as abdominal pain, weight loss, bleeding, dyspeptic symptoms, and iron deficiency anemia. We report a case of gastric IFP presented with microcytic anaemia, dyspepsia, malena and weight loss. Endosc...

We study the integrated fishery planning problem (IFP). In this problem, a fishery manager must schedule fishing trawlers to determine when and where the trawlers should go fishing and when the trawlers should return the caught fish to the factory. The manager must then decide how to process the fish into products at the factory. The objective is to maximize profit. We have found that IFP is di...

s / Osteoarthritis and Cartilage 25 (2017) S8eS75 S67 8 weeks with a slowly increasing running velocity from 10 m/min for 10 min, up to 20 m/min for 1 hour (n1⁄4 10), and a control group without running (n 1⁄4 10). Running takes place on a 5 lane motorized rodent treadmill (LE-8700; Panlab Harvard Apparatus). At starting point and after 8 weeks cartilage qPCR, micro-CT, histology and plasma FIB...

Abstract Background To investigate the in vitro and vivo anti-inflammatory/anti-fibrotic capacity of IFP-MSC manufactured as 3D spheroids. Our hypothesis is that do not require prior cell priming to acquire a robust immunomodulatory phenotype order efficiently reverse synovitis IFP fibrosis, secondarily delay articular cartilage damage vivo. Methods Human immunophenotype, tripotentiality, trans...

In this article, a distributed optimization problem is investigated via input feedforward passivity. First, an input-feedforward-passivity-based continuous-time algorithm proposed. It shown that the error system of proposed can be decomposed into group individual passive (IFP) systems interact with each other using output feedback information. Based on IFP framework, convergence conditions suit...

Colonic inflammatory fibroid polyp (IFP) is an uncommon benign polypoid lesion, which is composed of fibroblasts, numerous small vessels and edematous connective tissue with marked eosinophilic inflammatory cell infiltration. This condition is frequently detected in the stomach and small intestine, but uncommon in the colon. Although IFP is a benign lesion, surgical resections are performed in ...

PURPOSE The purpose is to investigate whether STI571, through platelet-derived growth factor receptor inhibition, enhances the therapeutic response to the chemotherapeutic drug epothilone B (EPO906) and, if so, to analyze the mechanism(s) underlying the effect. EXPERIMENTAL DESIGN SCID mice with s.c. human anaplastic thyroid carcinomas were treated with different doses of EPO906 alone or in c...