BACKGROUND Brivaracetam (BRV), eslicarbazepine acetate (ESL), lacosamide (LCM), and perampanel (PER) have been recently marketed as adjunctive treatments for focal onset seizures. To date, no randomized controlled trial (RCT) has directly compared BRV with ESL, LCM, or PER. PURPOSE To compare BRV with the other add-on AEDs in patients with uncontrolled focal epilepsy, estimating their efficac...

Long-term cognitive disability after TBI is associated with injury-induced neurodegeneration in the hippocampus-a region in the medial temporal lobe that is critical for learning, memory and executive function. Hence our studies focus on gene expression analysis of specific neuronal populations in distinct subregions of the hippocampus. The technique of laser capture microdissection (LCM), intr...

During persistent infection of mice with the lymphocytic choriomeningitis (LCM) virus approximately 3% of leukocytes were found to contain viral antigen and to produce infectious virus. Morphologically, infected cells were shown not to be lymphoblasts and their numbers were not reduced by removal of mononuclear phagocytes. We conclude that in LCM virus carrier mice true lymphocytes participate ...

We inspect digit stroke sets in LCM UpWrite space.

The paper provides a system theoretic characterisation of the least common multiple (LCM) m(s) of a given set of polynomials P which leads to an efficient numerical procedure for the computation of LCM that avoids root finding and use of greatest common divisor (GCD) procedures. The procedure that is presented also leads to the computation of the associated set of multipliers of P with respect ...

This article develops a computationally and analytically convenient form of the profile likelihood method for obtaining one-sided confidence limits on scalar-valued functions phi = phi(psi) of the parameters psi in a multiparameter statistical model. We refer to this formulation as the likelihood contour method (LCM). In general, the LCM procedure requires iterative solution of a system of nonl...

The combination of laser capture microdissection (LCM) and gene expression experiments allows cell specific expression profiling, which is decisive in cellular transcriptomic exploration. LCM makes possible the isolation of unique cells or group of cells, but maintaining RNA quality during this process is challenging. Several protocols are available for section preparation, but none of those gu...

We read with great interest the letter of Sodemann et al. on successful treatment of a patient with refractory absence status epilepticus (ASE) with lacosamide (LCM). In particular, Sodemann et al. reported the case of a 64-year-old male with juvenile absence epilepsy (he was on 400 mg/day lamotrigine, 400 mg/day topiramate and 2500 mg/day levetiracetam; plasma concentrations were not investiga...