Isopropyl Alcohal (IPA) is flammable, clear, colorless liquid and is slightly odorous. IPA has wide applications in various industries such as paint, pharmaceutical, lithography, rubber manufacture, semiconductor, and printing industries. It is one of the components of many antiseptic and cosmetic products. The exposure of high concentrations of IPA can cause depression in central nervous syste...

OBJECTIVE To compare a recently developed immunoprecipitation assay (IPA) to the mouse protection bioassay (MPB), currently considered the "gold standard", for detecting antibodies against botulinum toxin A (BTX-A) and to correlate these assay results with clinical responses to BTX-A injections. METHODS MPB and IPA assays were performed on serum samples from 83 patients (38 non-responders, 45...

Indoxyl sulfate (IS) induces fibrosis and inflammation in kidneys via oxidative stress through the induction of transforming growth factor-β1 (TGF-β1) and monocyte chemotactic protein-1 (MCP-1). Furthermore, IS is a potent endogenous agonist for aryl hydrocarbon receptor (AHR), which regulates the transcription of genes such as cytochrome P450 (CYP) 1A1. Indole-3-propionic acid (IPA) is an anti...

BACKGROUND Invasive pulmonary aspergillosis (IPA) remains an important cause of morbidity and mortality among patients undergoing solid organ transplantation (SOT). Because of the crude mortality of 80% to 90% in the absence of adequate treatment, timely diagnosis and early intervention with antifungal drugs are key factors in the successful treatment of IPA. Diagnosis, however, remains difficu...

BACKGROUND The hallux valgus interphalangeus (HVI) deformity is described as rare, but improved outcomes in hallux valgus (HV) surgery is associated with its surgical correction via an Akin osteotomy. The hypothesis of this study is that HVI is common and makes a significant contribution to the total valgus deformity of the hallux (TVDH). METHODS 285 pre-operative foot radiographs (193 with H...

Objective: Drawing on Finkel and Eckhardt’s I3 theory (Finkel & Eckhardt, 2013), this experimental study examined the effects of emotion regulatory efforts on aggressive verbalizations during anger arousal. Methods: Participants were 236 male and female college students with and without a history of intimate partner aggression (IPA) perpetration. Participants were randomized to 1 of 3 emotion r...

The efficacy of a new skin disinfectant, 2% (w/v) chlorhexidine gluconate (CHG) in 70% (v/v) isopropyl alcohol (IPA) (ChloraPrep), was compared with five commonly used skin disinfectants against Staphylococcus epidermidis RP62A in the presence or absence of protein, utilizing quantitative time-kill suspension and carrier tests. All six disinfectants [70% (v/v) IPA, 0.5% (w/v) aqueous CHG, 2% (w...

In a single-blind study six male patients (mean age 39.5 years) with moderate insomnia were treated with placebo for three nights, 100 mg indole-3-pyruvic acid (IPA) for three nights, 200 mg IPA for three nights, 100 mg IPA for two nights and placebo for two nights. Polygraphic recordings were made and total sleep time, sleep efficiency, sleep latency, slow wave sleep latency, rapid eye movemen...

Invasive pulmonary aspergillosis (IPA) is a life-threatening disease of immunocompromised patients that requires aggressive therapy. Detection of the disease and monitoring of the therapeutic response during IPA are complex, and current molecular diagnostics are not suitably robust. Here, we explored proteomic profiles of bronchoalveolar lavage fluid (BALF) specimens from a persistently neutrop...

A new algorithm is proposed for protein alignment based on their 3D structures. Initial protein matching uses comparison of their secondary structure elements. Each element of secondary structure is described by a vector representing its principal axis of inertia. All possible pairs of vectors from both proteins are chosen to compute similarity function values. A number of matched vector pairs ...