Transgenic or tumoral pancreatic islet beta cells with enhanced expression of low K(m) hexokinases (HK) exhibit a leftward shift of the normal dose-response curve for glucose-induced insulin release. Furthermore, HK catalyzes roughly 50% of total glucose phosphorylation measured in extracts from freshly isolated rodent islets, suggesting that HK participates in the process of glucose sensing in...

HK-2 human renal proximal tubule cells (RPTC) are commonly used in the in vitro study of “normal” RPTCs. We discovered recently that HK-2 cells are uncoupled from dopamine 1 receptor (D1R) adenylyl cyclase (AC) stimulation. We hypothesized that G protein–coupled receptor kinase type 4 (GRK4) single nucleotide polymorphisms may be responsible for the D1R/AC uncoupling in HK-2. This hypothesis wa...

Objective: To study the antianaphylactic, antihistaminic and mast cell stabilization activity of HK-07 in experimental animals. Materials and Methods: HK-07 is a polyherbal formulation containing extracts of various plant constituents. The compound HK-07 was evaluated using Wistar rats and Duncan Hartley guinea pigs. The antianaphylactic activity was investigated in rats using the active anaphy...

Hypoxia stimulates hepatocellular carcinoma (HCC) cell growth via hexokinase (HK) II induction, and alternatively, HK II inhibition induces apoptosis by activating mitochondrial signaling. This study was to investigate whether the induction of HK II by hypoxia is associated with enhanced mitochondrial stability and to confirm the apoptosis-inducing efficacy of HK II inhibitor in an in vivo mode...

در این پژوهش سعی می‌­شود مدلی برای شبیه‌­سازی چرخه عمر صنعت برق با استفاده از شبیه‌سازی عامل­بنیان ارائه شود، مدل، 5 عامل استخراج شد و شبیه­‌سازی به کمک نرم‌افزار Anylogic صورت پذیرفت. بهینه‌­سازی مدل چهار سناریو نظر خبرگان شد. سناریوی نخست، جذابیت نیروگاه گازی سیکل ترکیبی کاهش یافت بر دو دیگر افزوده نتیجه افزایش تولید آبی است که توجه کمبود منابع کشور به‌صرفه نیست. دوم ورود یک فناوری جدید میزان...

and Applied Analysis 3 Then, as L[a, b] ⊂ HK([a, b]) it holds that dim(L[a, b]) ≤ dim(HK([a, b])) ≤ card(HK([a, b])). Therefore, by Lemma 8, Corollary 7 and the known fact that c0 = c, we obtain the desired conclusion. Hereafter, the Alexiewicz topology and the topology induced by the norm of Proposition 9 will be denoted as τ A and τ ‖⋅‖ , respectively. Proposition 10. The topology τ ‖⋅‖ on HK...

HK-2 human renal proximal tubule cells (RPTC) are commonly used in the in vitro study of "normal" RPTCs. We discovered recently that HK-2 cells are uncoupled from dopamine 1 receptor (D(1)R) adenylyl cyclase (AC) stimulation. We hypothesized that G protein-coupled receptor kinase type 4 (GRK4) single nucleotide polymorphisms may be responsible for the D(1)R/AC uncoupling in HK-2. This hypothesi...

Muscle glucose uptake (MGU) is distributively controlled by three serial steps: delivery of glucose to the muscle membrane, transport across the muscle membrane, and intracellular phosphorylation to glucose 6-phosphate by hexokinase (HK). During states of high glucose fluxes such as moderate exercise, the HK activity is of increased importance, since augmented muscle perfusion increases glucose...

We show that the nonlinear wave equation u + ut = 0 is globally well-posed in radially symmetric Sobolev spaces Hk rad(R 3) × Hk−1 rad (R 3) for all integers k > 2. This partially extends the well-posedness in Hk(R3) × Hk−1(R3) for all k ∈ [1, 2], established by Lions and Strauss [12]. As a consequence we obtain the global existence of C∞ solutions with radial C∞ 0 data. The regularity problem ...