introduction: ultra low dose (uld) morphine induces hyperalgesia which is mediated by excitatory gscoupled opioid receptors. this study was designed to investigate the development of tolerance to hyperalgesic effect of morphine. also we attempt to seek possible similarity, in view of gs proteins, between hyperalgesic effect of uld and hyperalgesic effect after tolerance to hd. method: male wist...

T h ink o f the s tuden t s i n you r ma th c l a s s. I f the t e ache r we re to r andomly s e l e c t a boy and a g i r l f rom the c l a s s to comp le t e a p rob l em a t the boa rd , who wou ld have the advan t age ? Some peop l e wou ld s a y i t d epends on how the t e ache r t r e a t s the two s t anda rds. W ha t i f t he t e ache r t r e a t ed them the s ame — then wha t ? Wou ld ...

Wha t do you th ink makes the se peop l e have h i gh s e l f e s t e e m ? Examp le : Man y peop l e wou ld s a y T i g e r Woods ha s h i gh s e l f e s t e em . Why do you th ink tha t i s ? ( So l i c i t r e sponse s. Look fo r e xamp le s, such a s : h im be ing succe s s fu l , h a s a l o t o f f an s , i s g ood a t wha t he does , e t c . ) Self-Esteem: Does It Come From Success, Or I...

The v ideo games deve loped 20 yea r s ago had s imp le g r aph i c s and we ren’t ve r y r e a l i s t i c . However , new v ideo games a r e qu i t e complex , and they c an de p i c t r e a l i s t i c v io l en t s c enes. Many non-v io l en t v ideo games ex i s t ( such a s some spor t s games ) . However , the mos t f r equen t l y u sed g ames a r e the v io l en t ones. Effects of Viol...

Ka r e n i s wa lk i n g d own t h e h a l l w a y a n d s e e s o n e o f h e r f r i e n d s , B e t h , l o ok i n g s a d , a n d a sk s h e r wha t ’s w r o n g . B e t h r e p l i e s b y t e l l i n g Ka r e n t h a t s h e ’s a l i t t l e d e p r e s s e d b e c a u s e s h e g o t i n a f i g h t w i t h h e r mom t h a t mo r n i n g , b u t t h a t “ i t ’s n o t a b i g d e a l . ”...

I t ’s 11 : 30pm o n Monda y a n d Jo e , a n 18 y e a r o l d h i g h s c h o o l s e n i o r , j u s t g o t o u t o f w o rk a f t e r a f i v e h o u r s h i f t . H e h a s a ma t h a s s i g nm en t d u e i n t h e mo r n i n g a n d a h i s t o r y t e s t t omo r r ow a t n o o n . A l l h e wan t s t o d o i s g o t o b e d , b u t h e s t i l l h a s a l o t o f w o rk t o d o . W i t...

Here, we report the identification of dimethylarsinothioyl glutathione (DMMTA(V)(GS)) as a metabolite in cellular extracts of dimethyarsinous glutathione (Darinaparsin, DMA(III)(GS)) treated human multiple myeloma (MM) cell lines. Co-elution of sulfur and arsenic on the inductively coupled plasma mass spectrometer (ICP-MS) indicated the presence of sulfur along with arsenic in the newly observe...

The GTPase activity of the stimulatory guanine nucleotide-binding regulatory protein (Gs) of hormone-sensitive adenylate cyclase was investigated using purified rabbit hepatic Gs and either [alpha-32P]- or [gamma-32P] GTP as substrate. The binding of [35S]guanosine 5'-O-(thiotriphosphate) (GTP gamma S) was used to quantitate the total concentration of Gs. 1) GTPase activity was a saturable func...

Type 2 diabetes is characterized by reduced muscle glycogen synthesis. The key enzyme in this process, glycogen synthase (GS), is activated via proximal insulin signaling, but the exact molecular events remain unknown. Previously, we demonstrated that phosphorylation of Thr³⁰⁸ on Akt (p-Akt-Thr³⁰⁸), Akt2 activity, and GS activity in muscle were positively associated with insulin sensitivity. He...

Labow, Brian I., Wiley W. Souba, and Steve F. Abcouwer. Glutamine synthetase expression in muscle is regulated by transcriptional and posttranscriptional mechanisms. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E1136–E1145, 1999.— Skeletal muscle exports glutamine (Gln) and increases the expression of the enzyme glutamine synthetase (GS) in response to physiological stress. Acute stress or dire...