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تعداد نتایج: 126680  

Journal: :Gut 2010
Janine Rohrbach Nicola Robinson Gillian Harcourt Emma Hammond Silvana Gaudieri Meri Gorgievski Amalio Telenti Olivia Keiser Huldrych F Günthard Bernhard Hirschel Matthias Hoffmann Enos Bernasconi Manuel Battegay Hansjakob Furrer Paul Klenerman Andri Rauch

BACKGROUND Hepatitis C virus (HCV) infection is a major cause of morbidity in HIV infected individuals. Coinfection with HIV is associated with diminished HCV-specific immune responses and higher HCV RNA levels. AIMS To investigate whether long-term combination antiretroviral therapy (cART) restores HCV-specific T cell responses and improves the control of HCV replication. METHODS T cell re...

2010
David M Mosen Michael Horberg Douglas Roblin Christina M Gullion Richard Meenan Wendy Leyden Weiming Hu

OBJECTIVES Combination antiretroviral therapy (cART) is associated with increased survival among HIV-infected persons. Yet, no research to date has examined whether introduction of once-daily fixed-dosed combinations (FDC) affects the likelihood of cART initiation. We aimed to determine whether implementation of once-daily FDC regimens was associated with changes to cART initiation. We also ide...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003
Wing May Kong Sarah Stanley James Gardiner Caroline Abbott Kevin Murphy Asha Seth Ian Connoley Mohammed Ghatei David Stephens Stephen Bloom

We have recently shown that injection of the hypothalamic peptide cocaine and amphetamine regulated transcript (CART) into discrete hypothalamic nuclei stimulates food intake. This stimulation was particularly marked in the arcuate nucleus. Here we show that twice daily intra-arcuate injection of 0.2 nmole CART peptide for 7 days was associated with a 60% higher daytime food intake, an 85% high...

Journal: :The Journal of infectious diseases 2015
Vijaya Madhavi Fernanda E Ana-Sosa-Batiz Sinthujan Jegaskanda Rob J Center Wendy R Winnall Matthew S Parsons Jintanat Ananworanich David A Cooper Anthony D Kelleher Denise Hsu Sarah Pett Ivan Stratov Marit Kramski Stephen J Kent

BACKGROUND Combination antiretroviral therapy (cART) effectively controls human immunodeficiency virus (HIV) infection but does not eliminate HIV, and lifelong treatment is therefore required. HIV-specific cytotoxic T lymphocyte (CTL) responses decline following cART initiation. Alterations in other HIV-specific immune responses that may assist in eliminating latent HIV infection, specifically ...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه صنعتی اصفهان - دانشکده منابع طبیعی 1390

? در میان آلاینده های خاک فلزات سنگین به دلیل سمیت، تجمع پذیری و اثرات فیزیولوژیکی که بر موجودات زنده در غلظت های کم دارند، از اهمیت خاصی برخوردارند. این عناصر به دلیل تحرک کم به مرور در خاک انباشته می شوند. انباشت این عناصر در خاک در نهایت باعث ورود آن ها به چرخه غذایی و تهدید سلامت انسان و حیوانات می شود. عناصر سنگین بیشتر در لایه های سطحی خاک تجمع می یابند و در نتیجه بیشتر در معرض جدب و انتق...

Journal: :Journal of the American Chemical Society 2016

Journal: :Journal of the American Statistical Association 1998

Journal: :Computational Statistics 2021

We propose to extend CART for bivariate marked point processes provide a segmentation of the space into homogeneous areas interaction between marks. While usual tree considers marginal distribution response variable at each node, proposed algorithm, SpatCART, takes account spatial location observations in splitting criterion. introduce dissimilarity index based on Ripley’s intertype K-function ...

2016
Fatima W Kakkar Lindy Samson Wendy Vaudry Jason Brophy Jean-Baptiste Le Meur Normand Lapointe Stanley E Read Ari Bitnun

INTRODUCTION The optimal management of infants born to HIV-positive mothers who are untreated or have detectable viral load prior to delivery remains controversial. Despite the increasing use of combination antiretroviral therapy (cART) for post-exposure prophylaxis (PEP) of neonates at high risk of HIV infection, there is little safety and pharmacokinetic data to support this approach. The obj...

2009
Alexander O. Pasternak Suzanne Jurriaans Margreet Bakker Jan M. Prins Ben Berkhout Vladimir V. Lukashov

BACKGROUND Combination antiretroviral therapy (cART), the standard of care for HIV-1 infection, is considered to be successful when plasma viremia remains below the detection limit of commercial assays. Yet, cART fails in a substantial proportion of patients after the apparent success. No laboratory markers are known that are predictive of cART outcome in initial responders during the period of...

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