Background. Photodynamic therapy (PDT) has become a therapeutic option for basal cell carcinoma (BCC) in the last decade. Objectives. To study the results and predictors of BCC response to treatment with PDT and to evaluate fluorescence diagnosis of BCC. Methods. A descriptive, retrospective, and observational study was carried out. Patients with biopsy-confirmed BCC who were treated with methy...

Abbreviations used: F-FDG: fluor-18-fluorodeoxyglucose BCC: basal cell carcinoma CK: cytokeratin CT: computed tomography MRI: magnetic resonance imaging PET/CT: positron emission tomography and computed tomography INTRODUCTION The incidence rate of nonmelanoma skin cancer in the United States is estimated at 2.8 million new cases each year, of which, 80% are of basal cell carcinoma (BCC) type. ...

Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are the most frequent skin cancers in humans. An intact immune system is critical for protection against SCC since organ transplant recipients (OTR) have a 60- to 100-fold higher risk for developing these tumors. The role of the innate immune system in tumor immunosurveillance is unclear. Our aim was to determine the expression of sel...

Optical coherence tomography (OCT) has been shown to be of clinical value in imaging basal cell carcinoma (BCC). A novel dual OCT-video imaging system, providing automated registration of OCT and dermoscopy, has been developed to assess the potential of OCT in measuring the degree of sub-clinical spread of BCC. Seventeen patients selected for Mohs micrographic surgery (MMS) for BCC were recruit...

BACKGROUND Microcystic adnexal carcinoma (MAC), desmoplastic trichoepithelioma (DTE) and morpheaform basal cell carcinoma (BCC) frequently impose a considerable differential diagnostic challenge and immunohistochemistry is often used as a differentiating diagnostic adjunct. METHODS Using standard immunohistochemical techniques, we examined 21 examples of DTE, 17 examples of morpheaform BCC an...

The study of BCK-algebras was initiated by Iséki [7] as a generalization of the concept of set-theoretic difference and propositional calculus. Iséki posed an interesting problem; whether the class of BCK-algebras is a variety. In connection with this problem Komori introduced in [9] a notion of BCC-algebra which is a generalization of a BCK-algebra and proved that the class of all BCC-algebras...

Resource identity and composition structure bacterial community, which in turn determines the magnitude of bacterial processes and ecological services. However, the complex interaction between resource identity and bacterial community composition (BCC) has been poorly understood so far. Using aquatic microcosms, we tested whether and how resource identity interacts with BCC in regulating bacter...

BACKGROUND Aberrant activation of the Hedgehog (Hh) pathway is a key driver in the pathogenesis of basal cell carcinomas (BCCs), including patients with BCC nevus syndrome (BCCNS). It is unclear whether BCCs arising in patients with BCCNS respond differently to vismodegib than in patients without BCCNS. We examined the best overall response rate (BORR) and adverse events (AEs) of vismodegib in ...

BACKGROUND Basal cell carcinoma (BCC) can present with indolent or aggressive subtypes. These subtypes usually display vascular features, which are often readily identified using dermatoscopy. OBJECTIVE Dermatoscopy vascular features of aggressive BCC were compared to superficial, superficial and nodular, and nodular BCC for diagnostic discrimination. METHOD Dermatoscopy vascular features w...

The antigenic profile of basal cell carcinoma (BCC) cells was analyzed by immunoperoxidase staining of 27 surgically removed BCC lesions with antiganglioside, antiadhesion molecule, and antihistocompatibility locus antigen (HLA) monoclonal antibodies (MoAb). The large majority of BCC lesions were stained by antiganglioside MoAb; among the latter the anti-GD3 ganglioside MoAb R24 displayed the b...