Aortic valve (AoV) calcification is common in aged populations. Its subsequent aortic stenosis has been linked with increased morbidity, but still has no effective pharmacological intervention. Our previous data show endoplasmic reticulum (ER) stress is involved in AoV calcification. Here, we investigated whether deficiency of ER stress downstream effector CCAAT/enhancer-binding protein homolog...

Data on inclusive jet production in the transverse-momentum (pJ.) range 0-8 GeV /c for 200-GeV/c p, 1r-, 1r+, K-, K+, and]) incident on a hydrogen target are presented. The jet cross section is fully corrected for losses and biases, and compared with the predictions of a model based on quantum chromodynamics. Both the absolute cross section and the inclusive charged-particle distributions insid...

BACKGROUND Several mapping algorithms have been published with the EORTC-QLQ-C30 for estimating EQ-5D-3L utilities. However, none are available with EQ-5D-5L. Moreover, a comparison between mapping algorithms in the same set of patients has not been performed for these two instruments simultaneously. In this prospective data set of 100 non-small cell lung cancer (NSCLC) patients, we investigate...

The repeatability of DNA methylation measures may also affect the power of epigenome-wide association studies From Pierre-Antoine Dugué,* Dallas R English, Robert J MacInnis, Jihoon E Joo, Chol-Hee Jung and Roger L Milne Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Uni...

Vasoactive intestinal contractor (VIC)/endothelin-2 (ET2) is a vasoactive peptide hormone comprising 21 amino acids. The complete nucleotide sequence of the full-length gene encoding preproVIC (PPVIC) was determined. The PPVIC gene contains five exons that span 6 kb and shows a duplication on exons 2 and 3, coding for the VIC and VIC-like peptides respectively. Similarities between the genomic ...

BACKGROUND Intuitively, health and capability are distinct but linked concepts. This study aimed to quantify the link between a measure of health status (EQ-5D-3L) and capability (ICECAP-O) using regression-based methods. METHODS EQ-5D-3L and ICECAP-O data were collected from a sample of older people ( n = 584), aged over 65 years, requiring a hospital visit and/or care home resident, and rec...

To explore the relationship between neuraminidase immunity and the degree of attenuatíon of live influenza A virus vaccines, a comparative evaluation of three Victoria/75-ts-1[E] (Vic/75-ts-1[E]) recombinant viruses in serum hemagglutination-inhibiting-negative (titer, </=1:8) adult volunteers was performed. These three ts-1[E] viruses had a similar restriction of replication at 38 degrees C in...

Genomics and Epigenetics Division, Garvan Institute of Medical Research, NSW 2010, Australia St Vincent’s Clinical School, University of New South Wales, NSW 2052, Australia Bioinformatics Division, The Walter & Eliza Hall Institute of Medical Research, VIC 3052, Australia Department of Medical Biology, University of Melbourne, VIC 3010, Australia Department of Mathematics and Statistics, Unive...

_____________________________________________ Many young women today are concerned about their sexual health; an increasing number of them consult gynaecologists, youth centres (YCs) and general practitioners with vulvar problems such as painful sensations associated with vaginal intercourse (VIC). It is known that some women continue to have VIC despite pain. Theoretically, repeated painful VI...