In the field of positron emission tomography (PET) radiochemistry, compact microreactors provide reliable and reproducible synthesis methods that reduce the use of expensive precursors for radiolabeling and make effective use of the limited space in a hot cell. To develop more compact microreactors for radiosynthesis of 18F-labeled compounds required for the multistep procedure, we attempted ra...

To reduce culture artifacts by conventional repeated passaging and long-term culture in vitro, the isolation of synovial fibroblasts (SFB) was attempted from rheumatoid arthritis (RA) synovial membranes by trypsin/collagenase digest, short-term in vitro adherence (7 days), and negative isolation using magnetobead-coupled anti-CD14 monoclonal antibodies. This method yielded highly enriched SFB (...

Segmented filamentous bacteria (SFB) are commensal bacteria first identified in the ileum of mice and rats. Morphologically similar bacteria have been reported in a broad range of host species, however all strains have been refractory to in vitro culture thus far. While SFB were once considered innocuous members of the intestinal microbiota of laboratory rodents, they have now been shown to imp...

IL-17-expressing CD4+ T lymphocytes (Th17 cells) naturally reside in the intestine where specific cytokines and microbiota, such as segmented filamentous bacteria (SFB), promote their differentiation. Intestinal Th17 cells are thought to initially differentiate in the GALT and/or mesenteric lymph nodes upon Ag encounter and subsequently home to the lamina propria (LP) where they mediate effecto...

RORγt(+) Th17 cells are important for mucosal defenses but also contribute to autoimmune disease. They accumulate in the intestine in response to microbiota and produce IL-17 cytokines. Segmented filamentous bacteria (SFB) are Th17-inducing commensals that potentiate autoimmunity in mice. RORγt(+) T cells were induced in mesenteric lymph nodes early after SFB colonization and distributed across...

This Annual Report gives a summary of SFB results achieved in 2005. Also in its eighth year of funding, the overall scientific goal of the SFB is the design, verification, implementation , and analysis of numerical, symbolic, and geometrical methods for solving • large-scale direct and inverse problems with constraints and their synergetical use in scientific computing for real life problems of...

This paper aims to describe a deterministic generation of extreme waves in a typical towing tank. Such a generation involves an input signal to be provided at the wave maker in such a way that at a certain position in the wave tank, say at a position of a tested object, a large amplitude wave emerges. For the purpose, we consider a model called a spatial-NLS describing the spatial propagation o...

صلاخلا ــ ة : مت ةقرولا هذه يف ءاشنإ يف هدعاسملل مدقتم ماظن بناوج ذيفنتو ميمصت ضرع قتو و مي ءادأ حيحصت تارفش لأا ءاطخ ةليلق لا ةناتم ، ةينبم ىلع ءوفاكتلا رايتخا . موقي امه نيتيسيئر نيتفيظوب ةساردلا هذه يف مدقتملا ماظنلا : 1 ادأ باسحل ةيزاوتملا هاآاحملا ء تارفش حيحصت لأا ءاطخ ةليلق نمزب ةفاثكلا ادج ريصق ةنراقم ةمظنأب ةاآاحملا ةدوجوملا . 2 ةليلق ءاطخلأا حيحصت تارفشو فعضلا قطانم صحف نع ة...

This is a general overview document setting out the basics of ontology design for Project I1-[OntoSpace] and the SFB. First, a discussion of the major design parameters is given in order to familiarize SFB-members with the state of ontological engineering and the issues involved. We then select several key ontologies for discussion along the lines of the parameters introduced. We conclude by se...

Abstract Daily River Malaba flows recorded from 1999 to 2016 were modelled using seven lumped conceptual rainfall–runoff models including AWBM, SACRAMENTO, TANK, IHACRES, SIMHYD, SMAR and HMSV. Optimal parameters of each model obtained an automatic calibration strategy. Mismatches between observed assessed a total nine “goodness-of-fit” metrics. Capacity the reproduce historical hydrological ex...